Genetic variations on influenza virus infection outcomes in Moroccan patients.

IF 1.9 Q4 MICROBIOLOGY

Iranian Journal of Microbiology Pub Date : 2026-06-01 DOI:10.18502/ijm.v18i3.21662

Hassan Ihazmade, Zakia Regragui, Abderrahman Bimouhen, Imane Belbacha, Fatima El Falaki, Bouchra Benfathallah, Elmir Elharti, Soumia Triki, Khalid Sadki, Hicham Oumzil

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引用次数: 0

Abstract

Background and objectives: The influenza infection remains a significant global health challenge, it leads to illnesses that vary from mild to severe, and in certain cases, death. The innate immune response is the first line of defense against pathogen invaders; identification of variants associated with susceptibility or protection could further elucidate immune mechanisms and provide the basis for new therapeutic targets.

Materials and methods: We investigated four widely studied SNPs on the immune response to RNA infection in samples collected as part of sentinel influenza surveillance system. Of 1925 nasopharyngeal swabs collected from patients with Severe Acute Respiratory Infection (SARI) and Influenza-Like Illness (ILI), 115 samples were positive for ILI and 83 were positive for SARI. A third group of healthy individuals was also enrolled as a control. Genetic polymorphisms of the OAS3 (rs10735079), TYK2 (rs74956615) and APOBEC3G (rs8177832 and rs2294367) genes were genotyped using Human TaqMan SNP Genotyping Assays (ThermoFisher Scientific©). The association of Single Nucleotide Polymorphisms (SNPs) with ILI and SARI was investigated using SNPStats software.

Results: The rs2294367 in APOBECG3 show a strong and significant association with ILI and SARI across all genetic models, with a p-value<0.001 and OR between 2 and 6, while no association was found with rs8177832. The results for TYK2 suggest a potential protective effect, while the OAS3 SNP shows a strong and significant association with a decreased risk of Influenza infection specially with ILI group (OR<1 and p < 0.0001).

Conclusion: Our results open up a new perspective for new methods and strategies of therapy aimed to enhance the body's natural defenses against influenza virus infection.

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摩洛哥患者流感病毒感染结果的遗传变异

背景和目标：流感感染仍然是一项重大的全球卫生挑战，它会导致从轻微到严重不等的疾病，在某些情况下还会导致死亡。先天免疫反应是抵御病原体入侵的第一道防线；鉴定与易感性或保护性相关的变异可以进一步阐明免疫机制，并为新的治疗靶点提供基础。材料和方法：我们在流感哨点监测系统收集的样本中研究了四个广泛研究的与RNA感染免疫反应有关的snp。从严重急性呼吸道感染（SARI）和流感样疾病（ILI）患者收集的1925份鼻咽拭子中，115份样本ILI阳性，83份样本SARI阳性。第三组健康个体也被纳入作为对照。利用Human TaqMan SNP基因分型法对OAS3 （rs10735079）、TYK2 （rs74956615）和APOBEC3G （rs8177832和rs2294367）基因多态性进行分型（ThermoFisher Scientific©）。利用SNPStats软件研究了ILI和SARI与单核苷酸多态性（snp）的关系。结果：APOBECG3中rs2294367位点与ILI和SARI在所有遗传模型中均表现出强烈且显著的相关性，p值为8177832。结果表明TYK2具有潜在的保护作用，而OAS3 SNP与流感感染风险的降低（特别是ILI组）具有强烈而显著的相关性（or）。结论：我们的研究结果为旨在增强人体对流感病毒感染的自然防御的新方法和新策略开辟了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Microbiology MICROBIOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.