Orbital and Parotid Metastases from Nasopharyngeal Carcinoma: A Rare Case Presentation and Review of the Literature.

Abstract

Introduction: Nasopharyngeal carcinoma (NPC) is a rare, yet aggressive malignancy characterized by various clinical presentations. Metastasis to the orbital and parotid regions presents diagnostic challenges and adds complexity to the management.

Case presentation: Herein, we present a case of a 23-year-old male diagnosed with non-keratinizing undifferentiated NPC, initially presenting with orbital metastasis followed by parotid gland involvement shortly after completion of chemoradiotherapy. The patient underwent surgical intervention preceded by chemoradiotherapy, resulting in complete remission without recurrence over a 12-month follow-up period.

Conclusion: This case reinforces the critical importance of vigilant long-term surveillance in high-risk NPC patients with symptom-directed and risk-adapted surveillance approaches.