Incidence of Ulcerative Keratitis in the United States With and Without Predisposing Diabetes Mellitus.

IF 2.2 4区医学 Q2 OPHTHALMOLOGY

Eye & Contact Lens-Science and Clinical Practice Pub Date : 2026-09-01 Epub Date: 2026-06-17 DOI:10.1097/ICL.0000000000001293

Silanur Inanoglu, Wuqaas M Munir

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引用次数: 0

Abstract

Objectives: To assess the incidence of ulcerative keratitis (UK) in the United States between 2017 and 2024 and determine the risk of ulcerative keratitis development in patients with and without diabetes mellitus (DM).

Methods: The TriNetX analysis platform was used to retrospectively analyze data from US health care organizations and run analyses to calculate incidence rates of UK. Subsequently, patients with and without DM were identified to determine risk of UK development after propensity score matching for baseline demographic characteristics.

Results: The incidence rate of ulcerative keratitis fluctuated between 2017 to 2024, increasing to 30.06 cases per 100,000 person-years in 2024. Patients with DM exhibited increased risk of UK compared with those with no DM within one year of follow-up (RR, 1.601; 95% CI, 1.239-2.069). Among patients diagnosed with DM, those who had recorded hemoglobin A1c values greater than 8% exhibited increased risk of UK development compared with patients with hemoglobin A1c levels below 8% (RR, 1.14; 95% CI, 1.058-1.228).

Conclusions: UK incidence was found to increase to a high of 30.06 cases per 100,000 person-years in 2024. Increased risk of UK was also found with DM, particularly at hemoglobin A1c levels above 8%, underscoring how pathophysiological mechanisms underlying DM can negatively affect corneal health.

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溃疡性角膜炎的发病率在美国与不易感糖尿病。

目的：评估2017年至2024年间美国溃疡性角膜炎（英国）的发病率，并确定合并和不合并糖尿病（DM）的患者发生溃疡性角膜炎的风险。方法：采用TriNetX分析平台对美国卫生保健机构的数据进行回顾性分析，并进行分析计算英国的发病率。随后，在基线人口统计学特征的倾向评分匹配后，确定患有和不患有糖尿病的患者，以确定英国发展的风险。结果：溃疡性角膜炎的发病率在2017 - 2024年间波动，2024年上升至30.06例/ 10万人年。随访1年内，糖尿病患者与无糖尿病患者相比，患英国的风险增加（RR, 1.601; 95% CI, 1.239-2.069）。在诊断为糖尿病的患者中，记录的血红蛋白A1c值大于8%的患者与血红蛋白A1c水平低于8%的患者相比，英国发展的风险增加（RR, 1.14; 95% CI, 1.058-1.228）。结论：发现英国的发病率在2024年增加到每10万人年30.06例的高位。糖尿病患者患UK的风险也有所增加，特别是在糖化血红蛋白水平高于8%时，这强调了糖尿病的病理生理机制如何对角膜健康产生负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye & Contact Lens-Science and Clinical Practice OPHTHALMOLOGY-

CiteScore

4.50

自引率

4.30%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Eye & Contact Lens: Science and Clinical Practice is the official journal of the Contact Lens Association of Ophthalmologists (CLAO), an international educational association for anterior segment research and clinical practice of interest to ophthalmologists, optometrists, and other vision care providers and researchers. Focusing especially on contact lenses, it also covers dry eye disease, MGD, infections, toxicity of drops and contact lens care solutions, topography, cornea surgery and post-operative care, optics, refractive surgery and corneal stability (eg, UV cross-linking). Peer-reviewed and published six times annually, it is a highly respected scientific journal in its field.