Prevalence of Psychotic Symptoms and Their Clinical Correlates in Elderly Major Depressive Disorder Patients with Subclinical Hypothyroidism.

IF 3.7 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2026-01-01 Epub Date: 2026-06-15 DOI:10.1159/000552979

Xiu-Wen Wang, Min Li, Xiao-Qian Wang, Jian-Jun Zhang, Xiang-Yang Zhang

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引用次数: 0

Abstract

Introduction: In patients with major depressive disorder (MDD), thyroid dysfunction is highly correlated with depression severity and psychotic symptoms such as hallucinations and delusions. However, the prevalence and clinical correlates of psychotic symptoms in older MDD patients with subclinical hypothyroidism are rarely reported in China.

Methods: We recruited 172 older patients with first-episode and untreated MDD (aged ≥50 years). We used the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Positive and Negative Syndrome Scale positive subscale, and Global Impression of Severity Scale to assess depression, anxiety, psychotic symptoms, and disease severity, with each symptom/dimension evaluated in turn.

Results: The prevalence of psychotic symptoms was 18.6% (95% confidence interval: 13.5%-25.1%) in older MDD patients with subclinical hypothyroidism. Thyroid-stimulating hormone (TSH) and HAMA scores were clinical correlates for psychotic symptoms in older MDD patients with subclinical hypothyroidism.

Conclusions: Our results suggest that psychotic symptoms are common and higher TSH levels may indicate more psychotic symptoms in older MDD patients with subclinical hypothyroidism. Serum thyroid hormones screening is crucial in older MDD patients.

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老年重度抑郁症伴亚临床甲状腺功能减退患者精神病症状的患病率及其临床相关性

背景：在重度抑郁症（MDD）患者中，甲状腺功能障碍与抑郁严重程度和精神病性症状（如妄想和幻觉）高度相关。然而，在中国，老年MDD合并亚临床甲状腺功能减退患者精神病症状的患病率和临床相关性很少报道。方法：我们招募了172例首次发作且未经治疗的老年MDD患者（年龄≥50岁）。采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、阳性和阴性综合征量表阳性子量表和总体印象严重程度量表分别评估抑郁、焦虑、精神病症状和疾病严重程度。结果：老年MDD合并亚临床甲状腺功能减退患者精神症状的患病率为18.6±0.2%（32/172）。促甲状腺激素（TSH）和HAMA评分是老年MDD合并亚临床甲状腺功能减退患者精神病症状的临床相关性。结论：我们的研究结果表明，精神症状在老年MDD患者亚临床甲状腺功能减退中是常见的。较高的TSH水平可能表明老年MDD亚临床甲状腺功能减退患者有更多的精神病症状。血清甲状腺激素的筛查对老年重度抑郁症患者至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.