The Correlation Between the Prognostic Nutritional Index and Sudden Sensorineural Hearing Loss With Comorbid Nonalcoholic Fatty Liver Disease: A Prospective Study.

IF 1.7 3区医学 Q3 CLINICAL NEUROLOGY

Otology & Neurotology Pub Date : 2026-10-01 Epub Date: 2026-06-17 DOI:10.1097/MAO.0000000000004987

Xu Zhang, Maohua Wang, Daoming Bai, Rui Yang, Hanzhang Cao, Zhaojun Wang, Bing Guan, Chunping Yang

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引用次数: 0

Abstract

Objective: Sudden sensorineural hearing loss (SSNHL) is a frequent emergency in the field of otolaryngology. A comprehensive analysis of its clinical traits and risk factors is essential for clarifying its pathogenesis and creating effective prevention and treatment methods. The objective of this study was to investigate the correlation between the Prognostic Nutritional Index (PNI) and SSNHL in patients with comorbid nonalcoholic fatty liver disease (NAFLD).

Methods: This prospective study enrolled 120 SSNHL patients, who were subsequently divided into an NAFLD group and a non-NAFLD group. Using propensity score matching (PSM), a comparative analysis was conducted on clinical indicators between the two patient groups, including the severity, type, prognosis of SSNHL, and PNI levels.

Results: The analyses revealed that, compared with their non-NAFLD counterparts, patients with comorbid NAFLD exhibited significantly lower PNI levels, were older, had abnormal audiometric configurations, more severe hearing loss, and had a weaker prognosis. These variations are statistically remarkable. Across the various types of SSNHL patients, PNI levels progressively decreased as the disease severity progressed ( P < 0.001). However, no remarkable association was observed between PNI and the prognosis of SSNHL.

Conclusion: Among individuals with SSNHL, patients with comorbid NAFLD exhibit lower PNI levels, more severe hearing loss, and a weaker prognosis than those without NAFLD. A remarkable correlation was identified between PNI levels and both the severity and type of SSNHL. No significant association was found between PNI and the prognosis of SSNHL.

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预后营养指数与突发性感音神经性听力损失合并非酒精性脂肪性肝病的相关性：一项前瞻性研究

目的：突发性感音神经性听力损失（SSNHL）是耳鼻喉科常见的急症。全面分析其临床特点和危险因素，是明确其发病机制，制定有效防治方法的必要条件。本研究的目的是探讨共病非酒精性脂肪性肝病（NAFLD）患者预后营养指数（PNI）与SSNHL之间的相关性。方法：本前瞻性研究纳入120例SSNHL患者，随后将其分为NAFLD组和非NAFLD组。采用倾向评分匹配（propensity score matching， PSM）对两组患者SSNHL的严重程度、类型、预后、PNI水平等临床指标进行比较分析。结果：分析显示，与非NAFLD患者相比，合并NAFLD患者的PNI水平明显较低，年龄较大，听力配置异常，听力损失更严重，预后较差。这些变化在统计上是显著的。在不同类型的SSNHL患者中，PNI水平随着疾病严重程度的进展而逐渐降低（P < 0.001）。然而，PNI与SSNHL的预后无显著相关性。结论：在SSNHL患者中，合并NAFLD患者的PNI水平较低，听力损失较严重，预后较差。PNI水平与SSNHL的严重程度和类型之间存在显著相关性。PNI与SSNHL预后无显著相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otology & Neurotology 医学-耳鼻喉科学

CiteScore

3.80

自引率

14.30%

发文量

509

审稿时长

3-6 weeks

期刊介绍： Otology & Neurotology publishes original articles relating to both clinical and basic science aspects of otology, neurotology, and cranial base surgery. As the foremost journal in its field, it has become the favored place for publishing the best of new science relating to the human ear and its diseases. The broadly international character of its contributing authors, editorial board, and readership provides the Journal its decidedly global perspective.