Patch Test Reactions to Dental Materials: A Retrospective Single-Centre Study

IF 4.1 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2026-09-08 Epub Date: 2026-06-16 DOI:10.1111/cod.70205

Mojca Bizjak-Suran, Manca Marčun, Mitja Košnik, Dejan Dinevski

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引用次数: 0

Abstract

Background

Patch testing is used when delayed-type hypersensitivity to dental materials is suspected, but no European baseline series exists for patients with suspected allergy to dental materials.

Objectives

To describe patch test positivity to a 24-allergen dental series, assess the added yield of late readings at D6/7 and characterise methacrylate reactivity patterns.

Methods

In this retrospective single-centre study, 439 adults referred between 2016 and 2025 for suspected allergy to dental materials were patch tested with an institutional 24-allergen dental series comprising 11 metals, 8 methacrylates and 5 other substances. Reactions were read on D3 and D6/7 and scored by ICDRG criteria.

Results

Overall, 50.1% of patients had at least one positive reaction, and 41.0% had a positive metal reaction. Nickel (23.0%) and palladium (16.6%) were the most frequent allergens. Amongst methacrylates, HEMA (3.6%), HPMA (3.0%) and EGDMA (2.5%) were most frequent. Amongst methacrylate-positive patients, 44.4% had two or more positive reactions, 40.7% were HEMA-negative and 14.8% were HEMA-negative but HPMA-positive. Across all allergens, 19.8% of positive reactions were detectable only at D6/7, corresponding to a 24.7% relative increase in detection compared with D3 alone.

Conclusions

Late readings improved detection, and methacrylate reactivity was not fully captured by HEMA alone.

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贴片试验对牙科材料的反应：一项回顾性单中心研究。

背景：当怀疑对牙科材料有迟发性超敏反应时，使用斑贴试验，但对于怀疑对牙科材料过敏的患者，没有欧洲基线系列。目的：描述24种过敏原牙科系列的斑贴试验阳性，评估D6/7后期读数的增加产量，并表征甲基丙烯酸酯的反应模式。方法：在这项回顾性单中心研究中，2016年至2025年期间，439名疑似对牙科材料过敏的成年人接受了24种过敏原牙科系列的贴片测试，其中包括11种金属、8种甲基丙烯酸酯和5种其他物质。在D3和D6/7上阅读反应，并按ICDRG标准评分。结果：总体而言，50.1%的患者至少出现一次阳性反应，41.0%的患者出现金属阳性反应。镍（23.0%）和钯（16.6%）是最常见的过敏原。甲基丙烯酸酯中以HEMA（3.6%）、HPMA（3.0%）和EGDMA（2.5%）最为常见。在甲基丙烯酸酯阳性患者中，有两种或两种以上阳性反应的占44.4%，hema阴性的占40.7%，hema阴性但hpma阳性的占14.8%。在所有过敏原中，19.8%的阳性反应仅在D6/7检测到，与单独D3相比，检测相对增加24.7%。结论：较晚的读数改善了检测，仅靠HEMA不能完全捕获甲基丙烯酸酯的反应性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".