Bioactive biphenyl derivatives from Garcinia nujiangensis and structural revision

IF 2.9 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2026-07-01 Epub Date: 2026-06-15 DOI:10.1016/j.fitote.2026.107336

Feng Zhang, Lei Huang, Zhuohan Hu, Yanan Li, Jun Jin, Linlan Tao, Ping Yi, Xiaojiang Hao, Chunmao Yuan

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引用次数: 0

Abstract

Twelve biphenyl derivatives, including ten previously undescribed (1−10) and two known analogues (11 and 12), were isolated from the twigs and leaves of Garcinia nujiangensis. Two previously reported compounds, nujiangbiphenyls B and A were revised to garcinudiran I and J (9 and 10), respectively. Their structures were elucidated through comprehensive spectroscopic analysis, quantum chemical calculations, and X-ray crystallography. Subsequent α-glucosidase inhibitory effect revealed that five compounds (2, 6, 9, 10, and 11) exhibited more potential inhibitory effects than the positive control, with IC₅₀ values of 37.80 ± 1.43 to 147.70 ± 7.36 μg·mL⁻¹. Notably, compound 10 (IC₅₀ = 37.80 ± 1.43 μg·mL⁻¹) was identified as the most potent α-glucosidase inhibitor, which was approximately 7 times stronger than the positive control (acarbose). Additionally, six compounds (1, 2, 6, 7, 9, and 10) exhibited stronger lipid-lowering effects than the positive control (atorvastatin) in OA-induced HepG2 cells. This study expands the structural diversity of biphenyl derivatives from the genus Garcinia. It also provides promising anti-diabetic and lipid-lowering candidates for further investigation.

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查看原文本刊更多论文

怒江藤黄生物活性联苯衍生物及其结构修正。

从雨姜藤黄的枝条和叶子中分离得到12个联苯衍生物，包括10个先前未描述的（1-10）和2个已知的类似物（11和12）。两个先前报道的化合物，nujiangbiphenyls B和A被修正为garcinuddiran I和J（9和10）。通过综合光谱分析、量子化学计算和x射线晶体学对其结构进行了阐明。随后的α-葡萄糖苷酶抑制实验表明，5个化合物（2、6、9、10和11）比阳性对照表现出更强的潜在抑制作用，IC50值为37.80 ± 1.43 ~ 147.70 ± 7.36 μg·mL-1。其中，化合物10 （IC50 = 37.80 ± 1.43 μg·mL-1）的α-葡萄糖苷酶抑制作用最强，比阳性对照（阿卡波糖）强约7倍。此外，六种化合物（1、2、6、7、9和10）在oa诱导的HepG2细胞中表现出比阳性对照（阿托伐他汀）更强的降脂作用。本研究扩大了藤黄属联苯衍生物的结构多样性。它也为进一步研究提供了有前途的抗糖尿病和降脂候选物。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.