Tracking the Trail of Monkeypox: From Origins to Outbreak Control

IF 3.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Function Pub Date : 2026-06-16 DOI:10.1002/cbf.70239

Asha Jangir, Abhishek Swami, Neha Kumari, Hritik Kumar, Hemant Arya, Nisha Yadav, Diwakar Kumar, Tarun Kumar Bhatt

{"title":"Tracking the Trail of Monkeypox: From Origins to Outbreak Control","authors":"Asha Jangir, Abhishek Swami, Neha Kumari, Hritik Kumar, Hemant Arya, Nisha Yadav, Diwakar Kumar, Tarun Kumar Bhatt","doi":"10.1002/cbf.70239","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n <p>Monkeypox virus (<i>MPXV</i>), a zoonotic viral disease first identified in 1958, has re-emerged as a major global health concern. The first human case was reported in 1970 in the Democratic Republic of Congo (DRC), and since then, <i>MPXV</i> has demonstrated a clinical resemblance to smallpox, with transmission occurring through both animal-to-human and human-to-human contact. In 2022, the largest recorded outbreak resulted in over 30,000 cases across the Western Pacific, Asia, Europe, and the Americas. Subsequently, between 2022 and 2024, more than 100,000 confirmed cases were documented worldwide, leading the World Health Organization to declare <i>MPXV</i> a Public Health Emergency of International Concern (PHEIC) in August 2024. This review provides a comprehensive, up-to-date overview of <i>MPXV</i>, including its viral structure, life cycle, clinical manifestations, diagnostic strategies, vaccines, and emerging therapeutics. Furthermore, it examines current challenges in disease detection and control and identifies opportunities to strengthen surveillance, prevention, and treatment strategies. Overall, this article aims to serve as a consolidated resource on <i>MPXV</i>, highlighting its epidemiology, clinical significance, and implications for global public health preparedness.</p>\n </section>\n </div>","PeriodicalId":9669,"journal":{"name":"Cell Biochemistry and Function","volume":"44 6","pages":""},"PeriodicalIF":3.5000,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biochemistry and Function","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbf.70239","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Monkeypox virus (MPXV), a zoonotic viral disease first identified in 1958, has re-emerged as a major global health concern. The first human case was reported in 1970 in the Democratic Republic of Congo (DRC), and since then, MPXV has demonstrated a clinical resemblance to smallpox, with transmission occurring through both animal-to-human and human-to-human contact. In 2022, the largest recorded outbreak resulted in over 30,000 cases across the Western Pacific, Asia, Europe, and the Americas. Subsequently, between 2022 and 2024, more than 100,000 confirmed cases were documented worldwide, leading the World Health Organization to declare MPXV a Public Health Emergency of International Concern (PHEIC) in August 2024. This review provides a comprehensive, up-to-date overview of MPXV, including its viral structure, life cycle, clinical manifestations, diagnostic strategies, vaccines, and emerging therapeutics. Furthermore, it examines current challenges in disease detection and control and identifies opportunities to strengthen surveillance, prevention, and treatment strategies. Overall, this article aims to serve as a consolidated resource on MPXV, highlighting its epidemiology, clinical significance, and implications for global public health preparedness.

查看原文本刊更多论文

追踪猴痘的踪迹：从起源到爆发控制。

猴痘病毒（MPXV）是1958年首次发现的一种人畜共患病毒性疾病，现已重新成为一个主要的全球卫生问题。第一例人间病例于1970年在刚果民主共和国（DRC）报告，自那时以来，MPXV已显示出与天花的临床相似性，可通过动物与人之间和人与人之间的接触传播。2022年，有记录以来最大的一次疫情在西太平洋、亚洲、欧洲和美洲造成3万多例病例。随后，在2022年至2024年期间，全球记录的确诊病例超过10万例，导致世界卫生组织于2024年8月宣布MPXV为国际关注的突发公共卫生事件（PHEIC）。这篇综述提供了MPXV的全面、最新的概述，包括其病毒结构、生命周期、临床表现、诊断策略、疫苗和新兴治疗方法。此外，它审查了目前在疾病检测和控制方面面临的挑战，并确定了加强监测、预防和治疗战略的机会。总的来说，本文旨在作为MPXV的综合资源，强调其流行病学，临床意义和对全球公共卫生准备的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cell Biochemistry and Function 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Biochemistry and Function publishes original research articles and reviews on the mechanisms whereby molecular and biochemical processes control cellular activity with a particular emphasis on the integration of molecular and cell biology, biochemistry and physiology in the regulation of tissue function in health and disease. The primary remit of the journal is on mammalian biology both in vivo and in vitro but studies of cells in situ are especially encouraged. Observational and pathological studies will be considered providing they include a rational discussion of the possible molecular and biochemical mechanisms behind them and the immediate impact of these observations to our understanding of mammalian biology.