Synthesis and characterization of silver nanowires and their promising anticancer effects.

IF 6.4 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Nanoscale Horizons Pub Date : 2026-08-03 DOI:10.1039/d6nh00195e

William Emmanuel Ghann, Sk Md Atiqur Rahman, Shabib M Uddin, Rokshana Ara Ruhi, Md Anwarul Kabir Bhuiya, Md Shahnawaz Parvez, Mohsin Kazi, Mohammed Muzibur Rahman, Zmg Sarwar Jahangir, Mohammad Hossain Shariare, Md Abu Reza, Jamal Uddin

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Abstract

Silver nanowires (AgNWs) were synthesized by a modified polyol method and evaluated for their structural features and anticancer activity against Ehrlich ascites carcinoma (EAC) cells in vivo. The AgNWs were characterized by UV-vis spectroscopy, zeta potential analysis, dynamic light scattering, FESEM, TEM, and EDS to confirm their optical response, morphology, and elemental composition. The nanowires showed a plasmonic absorption band at 385 nm, a near-neutral zeta potential, and a mean diameter of 71.58 ± 22.78 nm, although minor secondary morphologies were observed. In the EAC mouse model, AgNWs reduced viable EAC cell counts in a non-linear dose-dependent manner, with the lower dose showing stronger inhibition than the higher dose. These findings suggest that AgNWs possess measurable anticancer activity, while also indicating that dispersion state and dose-dependent behavior require further mechanistic study before translational use can be considered.

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银纳米线的合成、表征及其抗癌作用。

采用改进的多元醇法合成了银纳米线（AgNWs），并对其结构特征和抗埃利希腹水癌（EAC）细胞的活性进行了体内评价。通过紫外可见光谱、zeta电位分析、动态光散射、FESEM、TEM和EDS等手段对AgNWs进行了表征，以确定其光学响应、形貌和元素组成。纳米线在385 nm处有等离子体吸收带，zeta电位接近中性，平均直径为71.58±22.78 nm，但存在次要形貌。在EAC小鼠模型中，AgNWs以非线性剂量依赖的方式降低EAC活细胞计数，低剂量比高剂量表现出更强的抑制作用。这些发现表明AgNWs具有可测量的抗癌活性，同时也表明在考虑转化应用之前，分散状态和剂量依赖行为需要进一步的机制研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nanoscale Horizons Materials Science-General Materials Science

CiteScore

16.30

自引率

1.00%

发文量

141

期刊介绍： Nanoscale Horizons stands out as a premier journal for publishing exceptionally high-quality and innovative nanoscience and nanotechnology. The emphasis lies on original research that introduces a new concept or a novel perspective (a conceptual advance), prioritizing this over reporting technological improvements. Nevertheless, outstanding articles showcasing truly groundbreaking developments, including record-breaking performance, may also find a place in the journal. Published work must be of substantial general interest to our broad and diverse readership across the nanoscience and nanotechnology community.