Ecological context for bacterial natural products discovery.

IF 12.5 1区 化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jonathan Parra, Marla I Macias-Contreras, Dulce G Guillén Matus, Katherine R Duncan
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引用次数: 0

Abstract

Covering: This review covers literature from 2015 to present.It is widely recognised that there is a significant gap between bacterial natural product potential and detected/described products. As such, there are several recent reviews on elicitation strategies for natural products discovery, which are often laboratory focused. Recently, a move to more ecology-focused approaches to understand the function of metabolites in nature and what impacts expression has been a growing trend. In this review, we aim to capture work done that goes beyond laboratory conditions and address ecological studies focussed on what impacts bacterial chemistry, covering both abiotic and biotic influences. We aim to touch on the impact of biodiversity loss, changes in ecosystems and future climate parameters and the implications this will have on natural products chemistry and biodiscovery efforts, the scale and consequences of which are not known.

细菌天然产物发现的生态环境。
内容:本综述涵盖了2015年至今的文献。人们普遍认为,细菌天然产物潜力与检测/描述产物之间存在显著差距。因此,最近有几篇关于天然产物发现的启发策略的综述,这些综述通常以实验室为重点。最近,一种以生态学为重点的方法来了解自然界代谢物的功能及其对表达的影响已经成为一种日益增长的趋势。在这篇综述中,我们的目标是捕获超越实验室条件的工作,并解决生态研究的重点是影响细菌化学的因素,包括非生物和生物影响。我们的目标是触及生物多样性丧失、生态系统变化和未来气候参数的影响,以及这将对天然产物化学和生物发现工作产生的影响,其规模和后果尚不清楚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Natural Product Reports
Natural Product Reports 化学-生化与分子生物学
CiteScore
21.20
自引率
3.40%
发文量
127
审稿时长
1.7 months
期刊介绍: Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.
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