Prognostic impact of malnutrition based on the global leadership initiative on malnutrition criteria in older patients undergoing liver resection for hepatocellular carcinoma.

IF 2.3 4区医学 Q2 SURGERY

Surgery Today Pub Date : 2026-10-01 Epub Date: 2026-06-15 DOI:10.1007/s00595-026-03363-4

Satoshi Omiya, Takeshi Urade, Shohei Komatsu, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto

{"title":"Prognostic impact of malnutrition based on the global leadership initiative on malnutrition criteria in older patients undergoing liver resection for hepatocellular carcinoma.","authors":"Satoshi Omiya, Takeshi Urade, Shohei Komatsu, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Masayuki Akita, Takuya Mizumoto, Jun Ishida, Yoshihide Nanno, Sadaki Asari, Hiroaki Yanagimoto, Masahiro Kido, Takumi Fukumoto","doi":"10.1007/s00595-026-03363-4","DOIUrl":null,"url":null,"abstract":"Purpose: This study aimed to evaluate preoperative malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and determine whether its prognostic impact after initial liver resection (LR) differs between older (≥70 years) and younger (<70 years) patients with hepatocellular carcinoma (HCC).Methods: This retrospective analysis included 330 patients with HCC who underwent LR between January 2011 and December 2019 at our institution. Overall survival (OS), recurrence-free survival (RFS), postoperative recurrence patterns, and treatment strategies for recurrence were compared between the two groups.Results: Among the 330 patients with HCC, 150 and 180 were classified into younger and older groups, respectively. Preoperative severe malnutrition was independently associated with OS (p=0.001) and RFS (p=0.044) in older patients and with RFS (p=0.039), but not OS, in younger patients. Moreover, in older patients, preoperative malnutrition was associated with a lower rate of aggressive treatments for intrahepatic recurrence (p=0.018) and a higher rate of extrahepatic recurrence (p=0.023) after LR, which was not observed in younger patients.Conclusions: Severe malnutrition, as per the GLIM criteria, is a significant independent predictor of OS and RFS in older patients with HCC who underwent LR. Preoperative malnutrition was associated with the treatment strategies for intrahepatic recurrence and the rate of extrahepatic recurrence in this population.","PeriodicalId":22163,"journal":{"name":"Surgery Today","volume":" ","pages":"2319-2329"},"PeriodicalIF":2.3000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgery Today","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00595-026-03363-4","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/15 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aimed to evaluate preoperative malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and determine whether its prognostic impact after initial liver resection (LR) differs between older (≥70 years) and younger (<70 years) patients with hepatocellular carcinoma (HCC).

Methods: This retrospective analysis included 330 patients with HCC who underwent LR between January 2011 and December 2019 at our institution. Overall survival (OS), recurrence-free survival (RFS), postoperative recurrence patterns, and treatment strategies for recurrence were compared between the two groups.

Results: Among the 330 patients with HCC, 150 and 180 were classified into younger and older groups, respectively. Preoperative severe malnutrition was independently associated with OS (p=0.001) and RFS (p=0.044) in older patients and with RFS (p=0.039), but not OS, in younger patients. Moreover, in older patients, preoperative malnutrition was associated with a lower rate of aggressive treatments for intrahepatic recurrence (p=0.018) and a higher rate of extrahepatic recurrence (p=0.023) after LR, which was not observed in younger patients.

Conclusions: Severe malnutrition, as per the GLIM criteria, is a significant independent predictor of OS and RFS in older patients with HCC who underwent LR. Preoperative malnutrition was associated with the treatment strategies for intrahepatic recurrence and the rate of extrahepatic recurrence in this population.

查看原文本刊更多论文

基于全球领导倡议的营养不良标准对老年肝癌肝切除术患者预后的影响。

目的：本研究旨在使用全球营养不良领导倡议（GLIM）标准评估术前营养不良，并确定其对初始肝切除术（LR）后的预后影响在老年人（≥70岁）和年轻人之间是否存在差异（方法：本回顾性分析包括330例2011年1月至2019年12月期间在我院接受LR的HCC患者）。比较两组患者的总生存期（OS）、无复发生存期（RFS）、术后复发方式及复发治疗策略。结果：330例HCC患者中，青年组150例，老年组180例。术前严重营养不良与老年患者的OS （p=0.001）和RFS （p=0.044）独立相关，与RFS （p=0.039）独立相关，但与年轻患者的OS无关。此外，在老年患者中，术前营养不良与LR后较低的肝内复发率（p=0.018）和较高的肝外复发率（p=0.023）相关，而在年轻患者中未观察到这一点。结论：根据GLIM标准，严重营养不良是行LR的老年HCC患者OS和RFS的重要独立预测因子。术前营养不良与该人群肝内复发和肝外复发率的治疗策略有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Surgery Today 医学-外科

CiteScore

4.90

自引率

4.00%

发文量

208

审稿时长

1 months

期刊介绍： Surgery Today is the official journal of the Japan Surgical Society. The main purpose of the journal is to provide a place for the publication of high-quality papers documenting recent advances and new developments in all fields of surgery, both clinical and experimental. The journal welcomes original papers, review articles, and short communications, as well as short technical reports("How to do it"). The "How to do it" section will includes short articles on methods or techniques recommended for practical surgery. Papers submitted to the journal are reviewed by an international editorial board. Field of interest: All fields of surgery.