Bromfenac with Sodium Bisulfite Inducing Contact Dermatitis and Corneal Ring Infiltrate: A Case Report.

IF 0.6 Q4 OPHTHALMOLOGY

Case Reports in Ophthalmology Pub Date : 2026-04-01 eCollection Date: 2026-01-01 DOI:10.1159/000551524

Christopher D Gelston, John J Fowler, Brittany M Perzia

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引用次数: 0

Abstract

Introduction: The aim of the study was to report a case of bromfenac with sodium bisulfite preservative induced contact dermatitis and a secondary sterile corneal ring infiltrate.

Case presentation: A 44-year-old male presented with a 1-week unilateral periocular dermatitis and eye redness. Initially the dermatitis responded to oral prednisone 80 mg and subsequent taper over 2 weeks. Upon tapering the prednisone, the patient returned with a recurrent dermatitis a week later. Dermatological workup included a skin biopsy demonstrating spongiotic dermatitis and a skin panel allergy test positive for sodium metabisulfite. The patient later mentioned self-administering bromfenac ophthalmic eye drops that contained sodium bisulfite. After the prolonged bromfenac use, the patient also developed a sterile corneal ring ulcer. The dermatitis finally resolved after discontinuing the bromfenac ophthalmic drops; however, the ring ulcer persisted after 3 months.

Conclusion: Topical bromfenac ophthalmic drops may induce a severe contact dermatitis related to the inactive ingredient sodium bisulfite within the solution. Chronic use of the bromfenac may also cause a sterile ring infiltrate. Caution should be given to patients in using eye drops with sulfite sensitivity or allergy.

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溴芬酸与亚硫酸氢钠致接触性皮炎及角膜环浸润1例报告。

简介：本研究的目的是报告一例溴芬酸伴亚硫酸氢钠防腐剂诱发的接触性皮炎和继发性无菌角膜环浸润。病例介绍：一名44岁男性，表现为1周的单侧眼周皮炎和眼睛发红。最初，口服强的松80毫克对皮炎有反应，随后在2周内逐渐减少。在逐渐减少泼尼松后，患者一周后复发皮炎。皮肤检查包括皮肤活组织检查显示海绵性皮炎和皮肤过敏试验对代谢亚硫酸钠阳性。病人后来提到自己服用含有亚硫酸氢钠的溴芬酸滴眼液。在长期使用溴芬酸后，患者还出现了无菌性角膜环溃疡。停用溴芬酸滴眼液后，皮炎最终消失；然而，环状溃疡在3个月后持续存在。结论：局部溴芬酸滴眼液可能引起严重的接触性皮炎，与溶液中的非活性成分亚硫酸氢钠有关。长期使用溴芬酸也可能导致无菌环浸润。对亚硫酸盐敏感或过敏的患者应谨慎使用滴眼液。

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来源期刊

Case Reports in Ophthalmology OPHTHALMOLOGY-

CiteScore

0.90

自引率

0.00%

发文量

129

审稿时长

12 weeks

期刊介绍： This peer-reviewed online-only journal publishes original case reports covering the entire spectrum of ophthalmology, including prevention, diagnosis, treatment, toxicities of therapy, supportive care, quality-of-life, and survivorship issues. The submission of negative results is strongly encouraged. The journal will also accept case reports dealing with the use of novel technologies, both in the arena of diagnosis and treatment. Supplementary material is welcomed. The intent of the journal is to provide clinicians and researchers with a tool to disseminate their personal experiences to a wider public as well as to review interesting cases encountered by colleagues all over the world. Universally used terms can be searched across the entire growing collection of case reports, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.