The Evolving Role of Surgery in Hepatocellular Carcinoma Management: From Resection to Multidisciplinary Strategy.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Investigation Pub Date : 2026-11-01 Epub Date: 2026-06-14 DOI:10.1080/07357907.2026.2681850

Takehiro Okabayashi, Motoyasu Tabuchi, Teppei Tokumaru, Sunao Uemura, Shuta Tamura

引用次数: 0

Abstract

Background: Hepatocellular carcinoma (HCC) frequently develops in the setting of chronic liver disease, making its management uniquely complex and historically centered on surgery.

Recent findings: Advances in locoregional therapies, molecular targeted agents, and immune checkpoint inhibitors have profoundly transformed treatment algorithms. Immunotherapy-based combinations achieve deep and durable responses, enabling downstaging, conversion surgery, and perioperative strategies previously considered unfeasible.

Conclusion: In the contemporary era, surgeons serve not only as technical operators but as strategic leaders within multidisciplinary teams, integrating evolving systemic and local therapies to achieve durable oncologic outcomes.

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手术在肝细胞癌治疗中的作用：从切除到多学科策略。

背景：肝细胞癌（HCC）经常发生在慢性肝病的背景下，使其治疗独特复杂，历史上以手术为中心。最近的发现：局部治疗、分子靶向药物和免疫检查点抑制剂的进展已经深刻地改变了治疗算法。以免疫治疗为基础的联合治疗实现了深度和持久的反应，使得降低分期、转换手术和以前认为不可行的围手术期策略成为可能。结论：在当代，外科医生不仅是技术操作员，而且是多学科团队的战略领导者，整合不断发展的系统和局部治疗，以实现持久的肿瘤疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Investigation 医学-肿瘤学

CiteScore

3.80

自引率

4.20%

发文量

审稿时长

8.5 months

期刊介绍： Cancer Investigation is one of the most highly regarded and recognized journals in the field of basic and clinical oncology. It is designed to give physicians a comprehensive resource on the current state of progress in the cancer field as well as a broad background of reliable information necessary for effective decision making. In addition to presenting original papers of fundamental significance, it also publishes reviews, essays, specialized presentations of controversies, considerations of new technologies and their applications to specific laboratory problems, discussions of public issues, miniseries on major topics, new and experimental drugs and therapies, and an innovative letters to the editor section. One of the unique features of the journal is its departmentalized editorial sections reporting on more than 30 subject categories covering the broad spectrum of specialized areas that together comprise the field of oncology. Edited by leading physicians and research scientists, these sections make Cancer Investigation the prime resource for clinicians seeking to make sense of the sometimes-overwhelming amount of information available throughout the field. In addition to its peer-reviewed clinical research, the journal also features translational studies that bridge the gap between the laboratory and the clinic.