Moving beyond associations: The role of mechanistic evidence in prenatal paracetamol safety.

IF 13.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2026-06-12 DOI:10.1016/j.medj.2026.101142

Athina Samara, Asma Khalil

引用次数: 0

Abstract

Prenatal paracetamol safety has been debated due to inconsistent observational findings and inherent confounding. Here we argue that epidemiology alone cannot resolve biological plausibility. Human-relevant mechanistic models, including organoid and microphysiological systems, can complement population studies by testing causal pathways, refining interpretation, and enabling integrated evidence triangulation to better inform clinical guidance.

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超越关联：机制证据在产前扑热息痛安全性中的作用。

由于不一致的观察结果和固有的混淆，产前扑热息痛的安全性一直存在争议。在这里，我们认为仅凭流行病学无法解决生物学上的合理性问题。与人类相关的机制模型，包括类器官和微生理系统，可以通过测试因果途径、完善解释和实现综合证据三角测量来补充人群研究，从而更好地为临床指导提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.