Chemoimmunotherapy enables adaptive strategies in locally advanced MSS colorectal cancer.

IF 13.3 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2026-06-12 DOI:10.1016/j.medj.2026.101145

Filippo Ghelardi, Filippo Pietrantonio

引用次数: 0

Abstract

Early exposure to checkpoint blockade restores immune-sensitivity in localized, immune-excluded cancers. In this issue of Med, Zhang et al. reported promising pathological activity of 3-month preoperative cadonilimab (bispecific anti-PD-1/CTLA-4 antibody) with modified FOLFOXIRI triplet intensive chemotherapy in patients with locally advanced MSS colorectal adenocarcinoma, hinting to new adaptive strategies of radiotherapy-sparing and organ preservation.¹.

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化疗免疫治疗使局部晚期MSS结直肠癌的适应性策略成为可能。

早期暴露于检查点阻断恢复局部免疫排斥癌症的免疫敏感性。在这一期的Med中，Zhang等报道了局部晚期MSS结直肠癌患者术前3个月卡多尼利单抗（双特异性抗pd -1/CTLA-4抗体）联合改良FOLFOXIRI三重强化化疗有很好的病理活性，提示了新的放疗-保留和器官保存的适应性策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.