Formulation of topical nano lipidic carrier gel encapsulating Gabapentin to combat peripheral neuropathic pain

Abstract

The present research focuses on the design, fabrication and optimization of NLC gel for topical delivery of Gabapentin for management of peripheral neuropathic pain. Particle size, zeta-potential, drug entrapment efficiency and in vitro drug release were the NLC characteristics initially established and optimized by means of quality by design. The optimized NLC formulation was a moderately polydisperse system (PDI = 0.331) with an average size of 144.4 nm and with zeta potential − 27.2 mV. After that, the 1% NLC gel was formulated using Carbopol 934 and exhibited an excellent homogeneity, spreadabilty, pH and extrudability. From the optimized NLC gel, 96.88 ± 0.02% drug was found to be released in in-vitro study after 6 h and follows the Higuchi drug release kinetics model. In an in-vivo study, wistar rats were treated with chronic constriction injury (CCI) that resulted in partial sciatic nerve denervation. The rats were treated with the developed NLC Gel, and the results showed promise in terms of heat sensitivity assessment like Tail-immersion test and Hot Plate test. In conclusion, Gabapentin containing NLC gel can be a better alternative to oral formulations and can be further explored for peripheral neuropathic pain.

Graphical Abstract

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