2D MoS2-conformal 3D-printed platform for dual-phototherapy and bone regeneration

IF 13.8 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nano Convergence Pub Date : 2026-06-13 DOI:10.1186/s40580-026-00559-9

Jong Hwa Seo, Inho Choi, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Chan Ho Moon, Ju Yeong Gwon, Nayoung Lee, Geonwoo Kim, Yun-Ha Cho, Sejin Choi, Hyojin Joo, Ji-Hye Kim, Eunsaem Song, Jihoon Kim, Dongjun Kim, Sungsu Kang, Dong Yun Lee, Donghyun Lim, Kisuk Yang, Gi Doo Cha, Soo-Hong Lee, Jungwon Park, Min-Ho Kang, Hyun-Do Jung

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引用次数: 0

Abstract

Osteosarcoma has poor prognosis owing to its aggressive metastasis and high recurrence rates due to residual cancer cells which are common even after surgical resection. In addition, for irregular defects, site-specific design is essential to ensure anatomical conformity. Consequently, a critical demand exists for a theragenerative approach that simultaneously provides structural reconstruction and functional eradication of residual cancer cells. Herein, we present a patient-specific 3D-printed theragenerative polyetheretherketone (PEEK) scaffold integrated with biofunctional 2D molybdenum disulfide (MoS₂) to impart enhanced bioactivity and dual-phototherapy. 2D monolayer MoS₂ synthesized via nanoseed-initiated atmospheric pressure chemical vapor deposition (APCVD) was subsequently integrated onto the 3D-printed PEEK through a polymer-assisted transfer process. The fabricated 2D MoS₂-conformal 3D-printed PEEK scaffold (MoS₂@PEEK) enabled simultaneous photothermal and photodynamic therapy via the intrinsic photoresponsive properties MoS₂. Under dual-wavelength irradiation, this combined phototherapy effectively induced pronounced cancer cell apoptosis and exhibited antibacterial activity through the synergistic effects of localized hyperthermia and reactive oxygen species generation. In contrast, under the same photothermal stimulation, pre-osteoblasts and vascular endothelial cells exhibited enhanced attachment, proliferation, and differentiation. Therefore, this theragenerative system represents a promising patient-specific platform for simultaneous tumor suppression, infection control, and bone regeneration after osteosarcoma resection.

Graphical abstract

The alternative text for this image may have been generated using AI.

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二维mos2适形3d打印双光疗和骨再生平台

骨肉瘤转移侵袭性强，手术切除后仍有残留的癌细胞，复发率高，预后差。此外，对于不规则缺陷，部位特异性设计是必要的，以确保解剖一致性。因此，迫切需要一种同时提供结构重建和功能根除残余癌细胞的再生方法。在此，我们提出了一种针对患者的3d打印热再生聚醚醚酮（PEEK）支架，该支架与生物功能2D二硫化钼（MoS2）相结合，以增强生物活性和双光疗。通过纳米种子引发的常压化学气相沉积（APCVD）合成的二维单层MoS2随后通过聚合物辅助转移工艺集成到3d打印的PEEK上。制备的二维MoS2共形3d打印PEEK支架（MoS2@PEEK）通过MoS2固有的光响应特性实现了同时光热和光动力治疗。在双波长照射下，这种联合光疗通过局部高热和活性氧生成的协同作用，有效地诱导了明显的癌细胞凋亡，并表现出抗菌活性。相反，在相同的光热刺激下，成骨前细胞和血管内皮细胞表现出增强的附着、增殖和分化。因此，这种再生系统代表了一个有希望的患者特异性平台，可以在骨肉瘤切除术后同时抑制肿瘤、控制感染和骨再生。图形抽象此图像的替代文本可能是使用AI生成的。

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来源期刊

Nano Convergence Engineering-General Engineering

CiteScore

15.90

自引率

2.60%

发文量

审稿时长

13 weeks

期刊介绍： Nano Convergence is an internationally recognized, peer-reviewed, and interdisciplinary journal designed to foster effective communication among scientists spanning diverse research areas closely aligned with nanoscience and nanotechnology. Dedicated to encouraging the convergence of technologies across the nano- to microscopic scale, the journal aims to unveil novel scientific domains and cultivate fresh research prospects. Operating on a single-blind peer-review system, Nano Convergence ensures transparency in the review process, with reviewers cognizant of authors' names and affiliations while maintaining anonymity in the feedback provided to authors.