Trends in Atrial Fibrillation-Related Mortality Among Adults With Obesity in the United States From 1999 to 2024.

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM

Obesity Science & Practice Pub Date : 2026-06-10 eCollection Date: 2026-06-01 DOI:10.1002/osp4.70160

Aymen Ahmed, Ruqiat Masooma Batool, Saad Ahmed Waqas, Hasan Fareed Siddiqui, Muhammad Sameer Arshad, Neha Saleem Paryani, Izza Shahid, Hasibullah Aminpoor, Ali Mithani, Muhammad Talha Ayub

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Abstract

Background: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with increased mortality, particularly among individuals with obesity. This study examined trends in AF-related mortality in adults with obesity in the United States from 1999 to 2024.

Methods: Trends in AF-related mortality in adults with obesity aged ≥ 25 years with obesity were analyzed using the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. AF and obesity were considered as multiple causes of death. Age-adjusted mortality rates (AAMRs) per 1,000,000 were analyzed using Joinpoint regression to identify trends and calculate average annual percentage change (AAPC) stratified by gender, race, and region.

Results: A total of 63,853 deaths were identified. From 1999 to 2024, AF-related mortality rates increased from 1.9 in 1999 to 20.8 in 2024 (AAPC: 11.4 [95% CI: 10.4, 12.2]). Males recorded higher AAMRs than females. White individuals exhibited higher AAMRs than Blacks. Nonmetropolitan areas (9.6) had higher AAMR than metropolitan areas (7.4). The Midwest recorded the highest AAMR while the South reported the steepest rise. States in the top 90th percentile of AAMR were Vermont, Oklahoma, Oregon, Minnesota, and Wyoming.

Conclusion: AF- and obesity-related mortality has increased overall from 1999 to 2024, with higher mortality rates observed in men, White individuals, nonmetropolitan areas, and the Southern US region. These findings highlight the need for continued surveillance and targeted prevention efforts in this population.

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1999年至2024年美国肥胖成人心房纤颤相关死亡率趋势

背景：心房颤动（AF）是一种常见的心律失常，与死亡率增加有关，特别是在肥胖人群中。这项研究调查了1999年至2024年美国成年肥胖患者af相关死亡率的趋势。方法：使用疾病控制与预防中心流行病学研究广泛在线数据（CDC WONDER）数据库分析≥25岁肥胖成人af相关死亡率趋势。房颤和肥胖被认为是多重死亡原因。使用Joinpoint回归分析每100万人的年龄调整死亡率（AAMRs），以确定趋势并计算按性别、种族和地区分层的平均年百分比变化（AAPC）。结果：共确定63,853例死亡。从1999年到2024年，af相关死亡率从1999年的1.9上升到2024年的20.8 （AAPC: 11.4 [95% CI: 10.4, 12.2]）。男性的aamr高于女性。白人个体的aamr高于黑人个体。非首都地区（9.6）的AAMR高于首都地区（7.4）。中西部地区的AAMR最高，而南部地区的增幅最大。AAMR排名前90%的州是佛蒙特州、俄克拉荷马州、俄勒冈州、明尼苏达州和怀俄明州。结论：从1999年到2024年，房颤和肥胖相关的死亡率总体上有所增加，在男性、白人、非大都市地区和美国南部地区观察到更高的死亡率。这些发现强调需要在这一人群中继续进行监测和有针对性的预防工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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