Concurrent Alcohol Use and Smoking Among US Adults with Hepatitis C.

IF 1.5 4区医学 Q3 PSYCHIATRY

Journal of Dual Diagnosis Pub Date : 2026-07-01 Epub Date: 2026-06-11 DOI:10.1080/15504263.2026.2676698

Mohammad Alabbas, Yuqi Guo, Jingyi Shi, Hongke Wu, Walaa Mahmoud, Shreya Sengupta, Omar T Sims

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引用次数: 0

Abstract

Objective: Concurrent alcohol use and smoking exert super-additive toxic effects that accelerate hepatic injury in people living with hepatitis C (HCV). Objectives of this study were to estimate the prevalence of concurrent alcohol use and active smoking at the population-level over the last decade among adults living with HCV in the United States (U.S.), examine trends in the prevalence of concurrent alcohol use and active smoking, and to identify risk factors associated with concurrent alcohol use and active smoking.

Methods: We conducted a repeated cross-sectional analysis using six NHANES cycles (2007-2018). The study population included adults aged ≥20 years with current HCV infection, defined as detectable HCV RNA with confirmatory anti-HCV seropositivity, and complete data on alcohol use and smoking status. Analyses incorporated NHANES' complex survey design (strata, primary sampling units, and MEC examination weights). Prevalence estimates and temporal trends were derived using design-based methods, with linear regression applied to test for trends. Associations were examined using design-adjusted multinomial logistic regression to calculate adjusted odds ratios (aORs).

Results: The pooled, survey-weighted prevalence of concurrent alcohol use and active smoking among adults living with HCV in the U.S. between 2007 and 2018 was 39.5%. Trends in the prevalence of concurrent alcohol use and active smoking did not decrease but instead remained relatively high over the 11-year period (Trend P = 0.71). In multivariate analysis, current marijuana use (aOR = 2.88, 95% CI 2.84-2.92), lifetime substance use (aOR = 5.98, 95% CI 5.87-6.10), depression (aOR = 2.59, 95% CI 2.55-2.63), and a history of cancer (aOR = 1.50, 95% CI 1.45-1.54) were positively associated with concurrent alcohol use and active smoking.

Conclusions: Markedly high and non-decreasing rates of concurrent alcohol use and active smoking at the population-level may contribute to higher incident cases of HCV-related morbidity and mortality in the near future.

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美国丙型肝炎成人同时饮酒和吸烟

目的：同时饮酒和吸烟对丙型肝炎（HCV）患者产生超加性毒性作用，加速肝损伤。本研究的目的是估计过去十年美国HCV成人患者同时饮酒和积极吸烟的流行情况，研究同时饮酒和积极吸烟的流行趋势，并确定与同时饮酒和积极吸烟相关的危险因素。方法：我们使用六个NHANES周期（2007-2018）进行了重复的横断面分析。研究人群包括年龄≥20岁且当前HCV感染的成年人，定义为可检测到的HCV RNA具有确定的抗HCV血清阳性，并且有完整的饮酒和吸烟状况数据。分析纳入了NHANES的复杂调查设计（地层、主要抽样单位和MEC检查权重）。使用基于设计的方法得出患病率估计和时间趋势，并应用线性回归来检验趋势。使用设计校正多项逻辑回归来计算校正优势比（aORs）来检验相关性。结果：2007年至2018年，美国丙型肝炎病毒感染者中同时饮酒和积极吸烟的合并调查加权患病率为39.5%。同时饮酒和主动吸烟的流行趋势并没有减少，反而在11年期间保持相对较高的水平（趋势P = 0.71）。在多变量分析中，当前大麻使用（aOR = 2.88, 95% CI 2.84-2.92）、终生物质使用（aOR = 5.98, 95% CI 5.87-6.10）、抑郁（aOR = 2.59, 95% CI 2.55-2.63）和癌症史（aOR = 1.50, 95% CI 1.45-1.54）与同时饮酒和积极吸烟呈正相关。结论：在人群水平上，同时饮酒和吸烟的显著高且不下降的比率可能在不久的将来导致hcv相关发病率和死亡率的升高。

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来源期刊

Journal of Dual Diagnosis Multiple-

CiteScore

4.90

自引率

13.60%

发文量

期刊介绍： Journal of Dual Diagnosis is a quarterly, international publication that focuses on the full spectrum of complexities regarding dual diagnosis. The co-occurrence of mental health and substance use disorders, or “dual diagnosis,” is one of the quintessential issues in behavioral health. Why do such high rates of co-occurrence exist? What does it tell us about risk profiles? How do these linked disorders affect people, their families, and the communities in which they live? What are the natural paths to recovery? What specific treatments are most helpful and how can new ones be developed? How can we enhance the implementation of evidence-based practices at clinical, administrative, and policy levels? How can we help clients to learn active recovery skills and adopt needed supports, clinicians to master new interventions, programs to implement effective services, and communities to foster healthy adjustment? The Journal addresses each of these perplexing challenges.