Targeting druggable ion channels to harness cancer cell mechanobiology for therapy.

IF 9.2 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2026-06-10 DOI:10.1016/j.devcel.2026.05.008

Beatrice Angi, Ildiko Szabo

引用次数: 0

Abstract

In this issue of Developmental Cell, Gajda et al.¹ identified the transcriptional partners and downstream targets of myocardin-related transcription factor A (MRTFA), a regulator of actin transcription and cancer cell stiffness. BK potassium channels emerged as pharmacological targets that stiffen cancer cells and enhance anti-tumor immune surveillance during metastasis.

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靶向药物离子通道利用癌细胞机械生物学进行治疗。

在本期《发育细胞》中，Gajda等人1确定了肌动蛋白转录和癌细胞硬度调节因子——心肌素相关转录因子A （MRTFA）的转录伙伴和下游靶点。BK钾通道成为硬化癌细胞和增强肿瘤转移过程中的抗肿瘤免疫监视的药理靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.