Correlation of hs-CRP and T lymphocyte subsets with severity and prognosis in elderly pulmonary infection.

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Journal of Infection in Developing Countries Pub Date : 2026-05-31 DOI:10.3855/jidc.22001

Yi Chen, Zhicong Liu, Yinan Chen, Jianfeng Zhong, Xiaoyong Li, Pengtao Song

{"title":"Correlation of hs-CRP and T lymphocyte subsets with severity and prognosis in elderly pulmonary infection.","authors":"Yi Chen, Zhicong Liu, Yinan Chen, Jianfeng Zhong, Xiaoyong Li, Pengtao Song","doi":"10.3855/jidc.22001","DOIUrl":null,"url":null,"abstract":"Introduction: This study aimed to investigate the correlation between high-sensitivity (hs)-CRP, T lymphocyte subset profiles, disease severity, and treatment outcomes in elderly patients with pulmonary infection.Methodology: The study included 85 elderly patients with respiratory infections (46 non-severe, 39 severe) and 79 healthy controls. The levels of hs-CRP, T lymphocyte subsets (CD4+/CD8+, CD4+, CD8+), and clinical pulmonary infection score (CPIS) were measured. Correlations with disease severity and CPIS were analyzed. Additionally, pre- and post-treatment levels of hs-CRP and T lymphocyte subsets were compared in patients with different treatment responses.Results: Patients had lower CD4+ counts and CD4+/CD8+ ratios, but higher hs-CRP, CD8+, and CPIS levels (p < 0.05) compared to controls. Severe cases had lower CD4+ and CD4+/CD8+, but higher CD8+, hs-CRP, and CPIS, than non-severe cases (p < 0.05). CD4+ and CD4+/CD8+ were negatively correlated with disease severity and CPIS, while hs-CRP and CD8+ were positively correlated (p < 0.05). The patients who responded to treatment (responders) had higher increases in hs-CRP, CD4+, and CD4+/CD8+ after 7 days of treatment, compared to non-responders; while CD8+ levels were lower (p < 0.05). Receiver operating characteristic (ROC) analysis showed that an hs-CRP difference cutoff of 5.31 had the highest predictive value for treatment outcomes, with 86.67% sensitivity and 68.57% specificity.Conclusions: hs-CRP and T lymphocyte subsets are closely associated with disease severity and treatment response in elderly patients with pulmonary infection, and their dynamic monitoring may aid in clinical prognosis evaluation.","PeriodicalId":49160,"journal":{"name":"Journal of Infection in Developing Countries","volume":"20 5","pages":"743-749"},"PeriodicalIF":1.3000,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection in Developing Countries","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3855/jidc.22001","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: This study aimed to investigate the correlation between high-sensitivity (hs)-CRP, T lymphocyte subset profiles, disease severity, and treatment outcomes in elderly patients with pulmonary infection.

Methodology: The study included 85 elderly patients with respiratory infections (46 non-severe, 39 severe) and 79 healthy controls. The levels of hs-CRP, T lymphocyte subsets (CD4+/CD8+, CD4+, CD8+), and clinical pulmonary infection score (CPIS) were measured. Correlations with disease severity and CPIS were analyzed. Additionally, pre- and post-treatment levels of hs-CRP and T lymphocyte subsets were compared in patients with different treatment responses.

Results: Patients had lower CD4+ counts and CD4+/CD8+ ratios, but higher hs-CRP, CD8+, and CPIS levels (p < 0.05) compared to controls. Severe cases had lower CD4+ and CD4+/CD8+, but higher CD8+, hs-CRP, and CPIS, than non-severe cases (p < 0.05). CD4+ and CD4+/CD8+ were negatively correlated with disease severity and CPIS, while hs-CRP and CD8+ were positively correlated (p < 0.05). The patients who responded to treatment (responders) had higher increases in hs-CRP, CD4+, and CD4+/CD8+ after 7 days of treatment, compared to non-responders; while CD8+ levels were lower (p < 0.05). Receiver operating characteristic (ROC) analysis showed that an hs-CRP difference cutoff of 5.31 had the highest predictive value for treatment outcomes, with 86.67% sensitivity and 68.57% specificity.

Conclusions: hs-CRP and T lymphocyte subsets are closely associated with disease severity and treatment response in elderly patients with pulmonary infection, and their dynamic monitoring may aid in clinical prognosis evaluation.

查看原文本刊更多论文

hs-CRP和T淋巴细胞亚群与老年肺部感染严重程度及预后的相关性

本研究旨在探讨老年肺部感染患者的高敏(hs)-CRP、T淋巴细胞亚群谱、疾病严重程度和治疗结果之间的相关性。方法：本研究纳入85例老年呼吸道感染患者（46例不严重，39例严重）和79例健康对照。检测hs-CRP水平、T淋巴细胞亚群（CD4+/CD8+、CD4+、CD8+）和临床肺部感染评分（CPIS）。分析疾病严重程度与CPIS的相关性。此外，比较不同治疗反应患者治疗前后hs-CRP和T淋巴细胞亚群水平。结果：与对照组相比，患者CD4+计数和CD4+/CD8+比值降低，hs-CRP、CD8+和CPIS水平升高（p < 0.05）。重症组CD4+、CD4+/CD8+低于非重症组，CD8+、hs-CRP、CPIS高于非重症组（p < 0.05）。CD4+、CD4+/CD8+与疾病严重程度、CPIS呈负相关，hs-CRP与CD8+呈正相关（p < 0.05）。治疗有反应的患者（应答者）在治疗7天后hs-CRP、CD4+和CD4+/CD8+的升高高于无应答者；CD8+水平降低（p < 0.05）。受试者工作特征（ROC）分析显示，hs-CRP差异截止值5.31对治疗结果的预测价值最高，敏感性为86.67%，特异性为68.57%。结论：hs-CRP和T淋巴细胞亚群与老年肺部感染患者病情严重程度和治疗反应密切相关，动态监测hs-CRP和T淋巴细胞亚群可用于临床预后评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.