{"title":"The Hemoglobin-Albumin-Lymphocyte-Platelet Score and Diabetic Neuropathy in Patients with Type 2 Diabetes Mellitus.","authors":"Aysun Şeker, Seydahmet Akin, Doğa Coşkun","doi":"10.1055/a-2890-1089","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diabetic neuropathy is a common microvascular complication of type 2 diabetes mellitus associated with chronic inflammation and metabolic dysregulation. The hemoglobin-albumin-lymphocyte-platelet score is a composite index reflecting nutritional and inflammatory status, but its association with diabetic neuropathy remains insufficiently characterized.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, 212 patients with type 2 diabetes mellitus were evaluated. Diabetic neuropathy was defined using electrophysiological criteria. Multivariable logistic regression analysis was performed to assess the association between the hemoglobin-albumin-lymphocyte-platelet score and diabetic neuropathy after adjustment for age, sex, diabetes duration, body mass index, and glycated hemoglobin. The hemoglobin-albumin-lymphocyte-platelet score was analyzed as a continuous variable (per 0.1-unit increase) and in quartiles. Receiver operating characteristic curve analysis was used to evaluate model discrimination.</p><p><strong>Results: </strong>Diabetic neuropathy was present in 45.2% of patients. The hemoglobin-albumin-lymphocyte-platelet levels were significantly lower in patients with diabetic neuropathy compared to those without diabetic neuropathy (0.36±0.18 vs. 0.72±0.39, <i>p</i><0.001). In multivariable analysis, the hemoglobin-albumin-lymphocyte-platelet score remained independently associated with diabetic neuropathy (odds ratio per 0.1-unit increase: 0.46, 95% confidence interval: 0.35-0.58, <i>p</i><0.001). Quartile analysis showed a graded inverse association (<i>p</i> for trend<0.001). The addition of the hemoglobin-albumin-lymphocyte-platelet score improved model discrimination compared to the base model (area under the curve: 0.868 vs. 0.567).</p><p><strong>Conclusions: </strong>The hemoglobin-albumin-lymphocyte-platelet score is inversely associated with diabetic neuropathy in patients with type 2 diabetes mellitus and may represent an integrated marker of metabolic and inflammatory burden.</p>","PeriodicalId":94001,"journal":{"name":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","volume":" ","pages":"338-343"},"PeriodicalIF":1.7000,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1055/a-2890-1089","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Diabetic neuropathy is a common microvascular complication of type 2 diabetes mellitus associated with chronic inflammation and metabolic dysregulation. The hemoglobin-albumin-lymphocyte-platelet score is a composite index reflecting nutritional and inflammatory status, but its association with diabetic neuropathy remains insufficiently characterized.
Methods: In this retrospective cross-sectional study, 212 patients with type 2 diabetes mellitus were evaluated. Diabetic neuropathy was defined using electrophysiological criteria. Multivariable logistic regression analysis was performed to assess the association between the hemoglobin-albumin-lymphocyte-platelet score and diabetic neuropathy after adjustment for age, sex, diabetes duration, body mass index, and glycated hemoglobin. The hemoglobin-albumin-lymphocyte-platelet score was analyzed as a continuous variable (per 0.1-unit increase) and in quartiles. Receiver operating characteristic curve analysis was used to evaluate model discrimination.
Results: Diabetic neuropathy was present in 45.2% of patients. The hemoglobin-albumin-lymphocyte-platelet levels were significantly lower in patients with diabetic neuropathy compared to those without diabetic neuropathy (0.36±0.18 vs. 0.72±0.39, p<0.001). In multivariable analysis, the hemoglobin-albumin-lymphocyte-platelet score remained independently associated with diabetic neuropathy (odds ratio per 0.1-unit increase: 0.46, 95% confidence interval: 0.35-0.58, p<0.001). Quartile analysis showed a graded inverse association (p for trend<0.001). The addition of the hemoglobin-albumin-lymphocyte-platelet score improved model discrimination compared to the base model (area under the curve: 0.868 vs. 0.567).
Conclusions: The hemoglobin-albumin-lymphocyte-platelet score is inversely associated with diabetic neuropathy in patients with type 2 diabetes mellitus and may represent an integrated marker of metabolic and inflammatory burden.
背景：糖尿病性神经病变（DN）是2型糖尿病（T2DM）常见的微血管并发症，与慢性炎症和代谢失调有关。血红蛋白-白蛋白-淋巴细胞-血小板（HALP）评分是反映营养和炎症状况的综合指标，但其与DN的关系仍未充分表征。方法对212例T2DM患者进行回顾性横断面研究。采用电生理标准定义DN。在调整年龄、性别、糖尿病病程、体重指数和HbA1c等因素后，采用多变量logistic回归分析评估HALP与DN之间的关系。HALP作为连续变量（每增加0.1个单位）和四分位数进行分析。采用受试者工作特征（ROC）曲线分析评价模型的判别性。结果糖尿病性神经病变占45.2%。与非DN患者相比，DN患者HALP水平显著降低（0.36±0.18比0.72±0.39,p < 0.001）。在多变量分析中，HALP仍然与DN独立相关（每增加0.1个单位OR: 0.46, 95% CI 0.35-0.58, p < 0.001）。四分位数分析显示分级负相关（p表示趋势< 0.001）。与基础模型相比，HALP的加入改善了模型判别（AUC 0.868 vs. 0.567）。结论HALP与T2DM患者糖尿病性神经病变呈负相关，可能是代谢和炎症负担的综合标志。
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