{"title":"Centrifugation Selective Plasma Exchange: A Novel Hybrid Modality Combining Centrifugal Separation and Membrane-Based Plasma Fractionation.","authors":"Takatoshi Sakurasawa, Atsushi Ohkubo, Soichiro Iimori, Shotaro Naito","doi":"10.1002/1744-9987.70163","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Therapeutic plasma exchange (TPE) is widely used for autoimmune diseases; however, current modalities involve trade-offs between molecular selectivity and vascular access requirements. We developed a novel hybrid modality, centrifugation selective plasma exchange (cSePE), combining centrifugal plasma separation with membrane-based plasma fractionation.</p><p><strong>Methods: </strong>Seven patients with autoimmune diseases underwent cSePE (15 sessions) between April 2024 and June 2025. Solute concentrations before and after treatment were measured, and hematocrit-adjusted removal ratios (RRs) were calculated.</p><p><strong>Results: </strong>The mean RR of IgG was 65.7% ± 11.1%, while fibrinogen reduction was limited to 29.8% ± 9.9%. Disease-specific autoantibodies showed RRs exceeding 45%. Serum albumin levels remained unchanged. No treatment-related complications were observed.</p><p><strong>Conclusions: </strong>cSePE enables selective removal of IgG fractions while preserving high-molecular-weight proteins and can be performed via peripheral venous access. This modality may represent a promising new option for plasma exchange in autoimmune diseases.</p>","PeriodicalId":94253,"journal":{"name":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","volume":" ","pages":"452-459"},"PeriodicalIF":1.2000,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/1744-9987.70163","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/8 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Background: Therapeutic plasma exchange (TPE) is widely used for autoimmune diseases; however, current modalities involve trade-offs between molecular selectivity and vascular access requirements. We developed a novel hybrid modality, centrifugation selective plasma exchange (cSePE), combining centrifugal plasma separation with membrane-based plasma fractionation.
Methods: Seven patients with autoimmune diseases underwent cSePE (15 sessions) between April 2024 and June 2025. Solute concentrations before and after treatment were measured, and hematocrit-adjusted removal ratios (RRs) were calculated.
Results: The mean RR of IgG was 65.7% ± 11.1%, while fibrinogen reduction was limited to 29.8% ± 9.9%. Disease-specific autoantibodies showed RRs exceeding 45%. Serum albumin levels remained unchanged. No treatment-related complications were observed.
Conclusions: cSePE enables selective removal of IgG fractions while preserving high-molecular-weight proteins and can be performed via peripheral venous access. This modality may represent a promising new option for plasma exchange in autoimmune diseases.
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