Correlation Analysis Between Tomographic, Biomechanical, and Chorioretinal Changes in Patients With Keratoconus.

IF 2.9 3区医学 Q1 OPHTHALMOLOGY

Journal of refractive surgery Pub Date : 2026-06-01 DOI:10.3928/1081597X-20260408-04

Meike Katharina Pandl, Hyeck-Soo Son, Maximilian Friedrich, Lucy Joanne Kessler, Maximilian Karl Köppe, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin

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引用次数: 0

Abstract

Purpose: To evaluate chorioretinal vascular changes in patients with keratoconus using optical coherence tomography angiography.

Methods: This mixed retrospective-prospective clinical study was conducted at University Eye Hospital in Heidelberg, Germany. A total of 184 eyes of 128 patients with keratoconus, 12 eyes with forme fruste keratoconus, and 100 eyes of 53 healthy control patients underwent comprehensive ocular examinations. Key parameters included corrected distance visual acuity, slit-lamp biomicroscopy, corneal tomography, and biomechanics. Assessed parameters included anterior/posterior radii of curvature, thinnest corneal thickness, maximum anterior sagittal curvature, flat/steep axis keratometric value, Belin/Ambrósio Enhanced Ectasia Deviation index, Tomographic Biomechanical Index, Corvis Biomechanical Index, Corvis Biomechanical Factor, E-staging, central macular thickness, and vessel density (VD) of the macular superficial capillary plexus (mSCP), macular deep capillary plexus (mDCP), and macular choriocapillaris. Keratoconus severity was classified using the ABCD grading system.

Results: In the keratoconus group, there was a significant increase in VD in the mSCP group (83.9 ± 4.04%) and the mDCP group (76.98 ± 5.5%) compared to the control group (mSCP: 78.29 ± 3.79%, mDCP: 71.07 ± 3.84%) (P < .00055 for both). These changes showed significant correlations with various clinical parameters, including the sum of the ABCD staging system (Rho = 0.33 for mSCP VD; Rho = 0.44 for mDCP VD).

Conclusions: This study revealed that macular SCP and DCP VDs are significantly increased in patients with keratoconus. Such vascular changes suggest an inflammatory component in keratoconus pathophysiology.

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圆锥角膜患者层析成像、生物力学和绒毛膜视网膜变化的相关性分析。

目的：应用光学相干断层扫描血管造影评价圆锥角膜患者的绒毛膜视网膜血管变化。方法：这项混合回顾性-前瞻性临床研究在德国海德堡大学眼科医院进行。对128例圆锥角膜患者184只眼、12例成形性圆锥角膜患者和53例健康对照患者100只眼进行眼部综合检查。关键参数包括矫正距离视力、裂隙灯生物显微镜、角膜断层扫描和生物力学。评估参数包括前/后曲率半径、最薄角膜厚度、最大前矢状曲率、平轴/陡轴角膜测量值、Belin/Ambrósio增强扩张偏离指数、断层生物力学指数、Corvis生物力学指数、Corvis生物力学因子、e分型、黄斑中央厚度、黄斑浅毛细血管丛（mSCP）、黄斑深毛细血管丛（mDCP）和黄斑绒毛膜毛细血管密度（VD）。采用ABCD分级系统对圆锥角膜的严重程度进行分级。结果：在圆锥角膜组中，mSCP组VD（83.9±4.04%）和mDCP组VD（76.98±5.5%）明显高于对照组（mSCP: 78.29±3.79%,mDCP: 71.07±3.84%）（P < 0.00055）。这些变化与ABCD分期系统的总和（mSCP VD的Rho = 0.33， mDCP VD的Rho = 0.44）等临床参数均有显著相关性。结论：本研究显示圆锥角膜患者黄斑SCP和DCP VDs明显增高。这种血管变化提示圆锥角膜病理生理中的炎症成分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

$Journal of refractive surgery$

Journal of refractive surgery 医学-外科

CiteScore

5.10

自引率

12.50%

发文量

160

审稿时长

4-8 weeks

期刊介绍： The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.