Jalumuri Ss Anjusha, Doniparthi V Seshagiri, Lakshminarayanapuram G Viswanathan, Shaik Ahmed, Sinu Ezhumalai, Binu V Sreekumaran Nair, Madhu Nagappa, Sanjib Sinha
{"title":"Sexual Health in Men and Women with Wilson's Disease: A Cross-Sectional Study.","authors":"Jalumuri Ss Anjusha, Doniparthi V Seshagiri, Lakshminarayanapuram G Viswanathan, Shaik Ahmed, Sinu Ezhumalai, Binu V Sreekumaran Nair, Madhu Nagappa, Sanjib Sinha","doi":"10.4103/aian.aian_109_26","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>Wilson's disease (WD) is a systemic copper toxicity disorder, manifesting as hepatic and neurological symptoms. Sexual health in WD is not well studied. This study aimed to understand sexual health impairment and its related factors in men and women with WD.</p><p><strong>Methods: </strong>Men with WD (MeWD) and women with WD (WoWD) were classified as being in the disease-active phase (DAP) or disease maintenance phase (DMP). Disease-related disability was assessed using the Global Assessment Scale for Wilson's Disease (GAS for WD). Sexual health was assessed with the Arizona Sexual Experience Scale (ASEX). Depression and anxiety were assessed using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales, respectively. Healthy men (MeH) and healthy women (WoH) underwent similar assessments for comparison.</p><p><strong>Results: </strong>The study included 48 MeWD (11 DAP, 37 DMP), 39 WoWD (12 DAP, 27 DMP), 29 MeH, and 34 WoH. In MeWD, ASEX scores (median [Q1-Q3]) were 13 (10-16) in DAP, 13 (11-14) in DMP, and 14 (12-16) in MeH, with no significant differences. However, in WoWD, ASEX scores were more impaired in DAP 19.5 (15.25-24.75) than in DMP 15 (14-17) ( P = 0.029) and WoH 14 (13-18) ( P = 0.025). ASEX scores correlated with GAS for WD in both MeWD ( P = 0.023) and WoWD ( P < 0.001), but not with 24-hour urinary copper excretion at diagnosis.</p><p><strong>Conclusions: </strong>Men and women with WD experience impaired sexual health, which may be related to disease-associated disability. Longitudinal disease registries are required to understand the role of copper metabolism in sexual health impairment in WD.</p>","PeriodicalId":8036,"journal":{"name":"Annals of Indian Academy of Neurology","volume":" ","pages":"579-584"},"PeriodicalIF":1.8000,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544868/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Indian Academy of Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/aian.aian_109_26","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/6/8 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objectives: Wilson's disease (WD) is a systemic copper toxicity disorder, manifesting as hepatic and neurological symptoms. Sexual health in WD is not well studied. This study aimed to understand sexual health impairment and its related factors in men and women with WD.
Methods: Men with WD (MeWD) and women with WD (WoWD) were classified as being in the disease-active phase (DAP) or disease maintenance phase (DMP). Disease-related disability was assessed using the Global Assessment Scale for Wilson's Disease (GAS for WD). Sexual health was assessed with the Arizona Sexual Experience Scale (ASEX). Depression and anxiety were assessed using the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) scales, respectively. Healthy men (MeH) and healthy women (WoH) underwent similar assessments for comparison.
Results: The study included 48 MeWD (11 DAP, 37 DMP), 39 WoWD (12 DAP, 27 DMP), 29 MeH, and 34 WoH. In MeWD, ASEX scores (median [Q1-Q3]) were 13 (10-16) in DAP, 13 (11-14) in DMP, and 14 (12-16) in MeH, with no significant differences. However, in WoWD, ASEX scores were more impaired in DAP 19.5 (15.25-24.75) than in DMP 15 (14-17) ( P = 0.029) and WoH 14 (13-18) ( P = 0.025). ASEX scores correlated with GAS for WD in both MeWD ( P = 0.023) and WoWD ( P < 0.001), but not with 24-hour urinary copper excretion at diagnosis.
Conclusions: Men and women with WD experience impaired sexual health, which may be related to disease-associated disability. Longitudinal disease registries are required to understand the role of copper metabolism in sexual health impairment in WD.
期刊介绍：
The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
