Malignant/Sarcomatous Transformation of Mixed Epithelial and Stromal Tumor of the Kidney: A Case Report.

IF 0.5 Q4 Medicine

IJU Case Reports Pub Date : 2026-05-25 eCollection Date: 2026-06-01 DOI:10.1002/iju5.70194

Kentaro Arinami, Kozue Ito, Go Hasegawa, Yurie Takizawa, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama

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Abstract

Introduction: Malignant transformation of mixed epithelial and stromal tumors of the kidney (MESTK) is extremely rare.

Case presentation: A 39-year-old man with gross hematuria was suspected to have renal cell carcinoma, measuring 13 cm in diameter. No distant metastases were observed. The patient underwent laparoscopic left nephrectomy. Histopathological examination revealed malignant sarcomatous transformation of MESTK. Immunohistochemically, the tumor was positive for PAX8, CD10, and desmin, as well as for estrogen, progesterone, and androgen receptors. Comprehensive genomic profiling did not yield any treatment recommendations or relevant information. The patient will be closely monitored for any signs of recurrence or metastasis.

Conclusion: The associated prognosis for patients with nonmetastatic MESTKs exhibiting malignant transformation is unknown; however, strict follow-up is recommended due to the histological grade of malignancy and local invasion.

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肾上皮和间质混合瘤的恶性/肉瘤转化1例报告。

导读：肾上皮和间质混合瘤的恶性转化（MESTK）极为罕见。病例介绍：39岁男性，肉眼血尿疑似肾细胞癌，直径13cm。未见远处转移。患者行腹腔镜左肾切除术。组织病理学检查显示MESTK为恶性肉瘤转化。免疫组织化学结果显示，肿瘤PAX8、CD10、desmin以及雌激素、孕激素和雄激素受体呈阳性。全面的基因组分析没有产生任何治疗建议或相关信息。将密切监测患者是否有复发或转移的迹象。结论：伴有恶性转化的非转移性MESTKs患者预后未知；然而，由于肿瘤的组织学分级和局部侵袭，建议严格随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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