Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia

IF 3.4 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research Pub Date : 2026-06-07 DOI:10.1002/mpr.70082

Zhengquan Chen, Yiming Wu, Zuowei Wang, Jun Wang, Chao Jiang, Wenchao Shen, Yanting Zheng, Yi Wu

{"title":"Social and Clinical Factors Associated With Antipsychotic Medication Discontinuation in Patients With Schizophrenia","authors":"Zhengquan Chen, Yiming Wu, Zuowei Wang, Jun Wang, Chao Jiang, Wenchao Shen, Yanting Zheng, Yi Wu","doi":"10.1002/mpr.70082","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This cross-sectional case-control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous-treatment patients. Assessed factors covered demographics, clinical profiles, and scores from the Positive and Negative Syndrome Scale (PANSS), the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Personal and Social Performance (PSP) scale.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Patients in the discontinuation group demonstrated significantly higher employment rates (<i>χ</i><sup>2</sup> = 24.514, <i>p</i> < 0.001) and marriage rates (<i>χ</i><sup>2</sup> = 14.970, <i>p</i> = 0.002) compared to those in the continuous treatment group. The continuous treatment group had more episodes (<i>p</i> < 0.001) and severe symptoms (PANSS, <i>p</i> < 0.001) with lower cognitive (RBANS, <i>p</i> = 0.001) and social functioning scores (PSP, <i>p</i> < 0.001) compared to the discontinuation group. Regression analysis revealed that fewer episodes (<i>β</i> = 2.799, <i>p</i> = 0.018) and lower PANSS negative symptom scores (<i>β</i> = 0.533, <i>p</i> = 0.011) were associated with a greater likelihood of medication discontinuation.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The discontinuation group exhibited milder schizophrenia symptoms and higher social functioning than the continuation group. Furthermore, patients with fewer episodes and milder negative symptoms were more likely to discontinue medication.</p>\n </section>\n </div>","PeriodicalId":50310,"journal":{"name":"International Journal of Methods in Psychiatric Research","volume":"35 2","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2026-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mpr.70082","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Methods in Psychiatric Research","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/mpr.70082","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives

This study aims to identify social and clinical factors associated with antipsychotic medication discontinuation in patients with schizophrenia.

Methods

This cross-sectional case-control study comprised 111 schizophrenia patients, including 55 who discontinued medication on their own initiative and 56 matched continuous-treatment patients. Assessed factors covered demographics, clinical profiles, and scores from the Positive and Negative Syndrome Scale (PANSS), the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and the Personal and Social Performance (PSP) scale.

Results

Patients in the discontinuation group demonstrated significantly higher employment rates (χ² = 24.514, p < 0.001) and marriage rates (χ² = 14.970, p = 0.002) compared to those in the continuous treatment group. The continuous treatment group had more episodes (p < 0.001) and severe symptoms (PANSS, p < 0.001) with lower cognitive (RBANS, p = 0.001) and social functioning scores (PSP, p < 0.001) compared to the discontinuation group. Regression analysis revealed that fewer episodes (β = 2.799, p = 0.018) and lower PANSS negative symptom scores (β = 0.533, p = 0.011) were associated with a greater likelihood of medication discontinuation.

Conclusion

The discontinuation group exhibited milder schizophrenia symptoms and higher social functioning than the continuation group. Furthermore, patients with fewer episodes and milder negative symptoms were more likely to discontinue medication.

查看原文本刊更多论文

精神分裂症患者停用抗精神病药物的社会和临床因素

目的：本研究旨在确定与精神分裂症患者停用抗精神病药物相关的社会和临床因素。方法：本横断面病例对照研究纳入111例精神分裂症患者，其中55例主动停药，56例匹配的持续治疗患者。评估的因素包括人口统计、临床概况、阳性和阴性综合征量表（PANSS）、神经心理状态评估可重复电池（rban）和个人与社会表现（PSP）量表的得分。结果：停药组患者就业率明显高于持续治疗组（χ2 = 24.514, p 2 = 14.970, p = 0.002）。结论：停药组精神分裂症症状较继续治疗组轻，社会功能较继续治疗组高。此外，发作次数较少和阴性症状较轻的患者更有可能停药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Methods in Psychiatric Research 医学-精神病学

CiteScore

5.20

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.