{"title":"Ultrasound-responsive drug nanocarriers in oncology: key determinants of therapeutic performance.","authors":"Fahima Reete, Zimei Wu, Sachin S Thakur","doi":"10.1080/08982104.2026.2681623","DOIUrl":null,"url":null,"abstract":"<p><p>Carrier-based systems, particularly liposomes, continue to be widely investigated for delivering anticancer treatments. In recent years, multiple approaches have been explored to achieve on-demand delivery of therapeutic cargo from these systems. Here, ultrasound has come to the fore as a practical and precise stimulus to trigger drug release from various formulations. This review explores the interplay between ultrasound and different micro and nanocarriers in oncology, highlighting the mechanisms of ultrasound-triggered delivery, relevance of carrier composition and particle size, cancer types in which the technique holds the most promise, and current barriers and future opportunities related to this approach. We also summarize the existing preclinical studies of US-responsive carriers, with a focus on lipid-based delivery systems. Through the review, the clinical translatability of high-intensity focused ultrasound in drug delivery platform designs is showcased.</p>","PeriodicalId":16286,"journal":{"name":"Journal of Liposome Research","volume":" ","pages":"1-19"},"PeriodicalIF":4.7000,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Liposome Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08982104.2026.2681623","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Carrier-based systems, particularly liposomes, continue to be widely investigated for delivering anticancer treatments. In recent years, multiple approaches have been explored to achieve on-demand delivery of therapeutic cargo from these systems. Here, ultrasound has come to the fore as a practical and precise stimulus to trigger drug release from various formulations. This review explores the interplay between ultrasound and different micro and nanocarriers in oncology, highlighting the mechanisms of ultrasound-triggered delivery, relevance of carrier composition and particle size, cancer types in which the technique holds the most promise, and current barriers and future opportunities related to this approach. We also summarize the existing preclinical studies of US-responsive carriers, with a focus on lipid-based delivery systems. Through the review, the clinical translatability of high-intensity focused ultrasound in drug delivery platform designs is showcased.
期刊介绍：
The Journal of Liposome Research aims to publish original, high-quality, peer-reviewed research on the topic of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. Reviews and commentaries or editorials are generally solicited and are editorially reviewed. The Journal also publishes abstracts and conference proceedings including those from the International Liposome Society.
The scope of the Journal includes:
Formulation and characterisation of systems
Formulation engineering of systems
Synthetic and physical lipid chemistry
Lipid Biology
Biomembranes
Vaccines
Emerging technologies and systems related to liposomes and vesicle type systems
Developmental methodologies and new analytical techniques pertaining to the general area
Pharmacokinetics, pharmacodynamics and biodistribution of systems
Clinical applications.
The Journal also publishes Special Issues focusing on particular topics and themes within the general scope of the Journal.
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