Pediatric non-gestational choriocarcinoma: systematic literature review and a multicenter case series.

IF 4.2 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Journal of Gynecologic Oncology Pub Date : 2026-07-01 Epub Date: 2026-05-29 DOI:10.3802/jgo.2026.37.e81

Lin Yang, Shen Yang, Jinghao Yan, Haiyan Cheng, Jun Feng, Xin Feng, Xiaofeng Chang, Zhiyun Zhu, Deguang Meng, Xianwei Zhang, Hong Qin, Huanmin Wang, Jianguo Zhang, Wei Yang

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引用次数: 0

Abstract

Objective: This study aimed to explore the key factors affecting the prognosis of pediatric non-gestational choriocarcinoma (PNGC), providing evidence for optimizing clinical treatment and prognosis evaluation.

Methods: A systematic literature review was conducted based on online searches of PubMed, Science Direct, and Google Scholar. A retrospective analysis of multi-center pediatric PNGC patients was performed for the period from 2014 to 2024.

Results: All four patients in our series achieved complete remission and long - term survival following comprehensive treatment. A total of 19 studies involving 70 patients met the inclusion and exclusion criteria for the Systematic search of the literature. Among the 74 patients in this study, 40 received comprehensive treatment. The 3-year overall survival (OS) rate was 50.8%. Univariate survival analysis indicated that age, primary tumor location, and treatment modality influenced OS. However, multivariate analysis revealed that only single - modality treatment or no treatment was associated with an unfavorable prognosis.

Conclusion: PNGC is a rare and aggressive disease associated with therapeutic challenges and a poor long-term prognosis. The prognosis analysis reveals that the comprehensive treatment plays a crucial role in improving the therapeutic outcome.

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儿童非妊娠期绒毛膜癌：系统文献综述和多中心病例系列。

目的：探讨影响儿童非妊娠期绒毛膜癌（PNGC）预后的关键因素，为优化临床治疗及预后评价提供依据。方法：通过PubMed、Science Direct、谷歌Scholar等在线检索进行系统文献综述。对2014 - 2024年多中心小儿PNGC患者进行回顾性分析。结果：在我们的系列中，所有4例患者在综合治疗后均获得完全缓解和长期生存。共有19项研究，涉及70例患者，符合文献系统检索的纳入和排除标准。在本研究的74例患者中，有40例接受了综合治疗。3年总生存率（OS）为50.8%。单因素生存分析表明，年龄、原发肿瘤位置和治疗方式影响OS。然而，多变量分析显示，只有单一模式的治疗或不治疗与不良预后相关。结论：PNGC是一种罕见的侵袭性疾病，治疗困难，长期预后差。预后分析表明，综合治疗对改善治疗效果起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gynecologic Oncology ONCOLOGY-OBSTETRICS & GYNECOLOGY

CiteScore

6.00

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Gynecologic Oncology (JGO) is an official publication of the Asian Society of Gynecologic Oncology. Abbreviated title is ''J Gynecol Oncol''. It was launched in 1990. The JGO''s aim is to publish the highest quality manuscripts dedicated to the advancement of care of the patients with gynecologic cancer. It is an international peer-reviewed periodical journal that is published bimonthly (January, March, May, July, September, and November). Supplement numbers are at times published. The journal publishes editorials, original and review articles, correspondence, book review, etc.