A Bibliometric and Visualization Analysis of Global Trends and Research Frontiers on Contrast-Enhanced Ultrasound in Liver Diseases

IF 1.3 4区医学 Q3 ACOUSTICS

Journal of Clinical Ultrasound Pub Date : 2026-10-06 Epub Date: 2026-06-07 DOI:10.1002/jcu.70291

Marcela Celiberti Soveral, Victor Arthur Ohannesian, Giovana Baracat Alvarez, Bruno Marçola Ishizuka, Matheus Almeida Cabral, Priscila Mina Falsarella, Pedro Henrique Machado Carani, Victor Arantes Jabour, Guilherme Ciconelli Del Guerra, Miguel José Francisco-Neto, Marcelo Rocha Corrêa da Silva, Antonio Rahal-Junior, Rodrigo Gobbo Garcia, Marcos Roberto Gomes de Queiroz

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引用次数: 0

Abstract

Objectives

This study aims to perform a comprehensive bibliometric analysis to map global research trends, thematic concentrations, and knowledge gaps in Contrast-enhanced ultrasound (CEUS) applied to liver diseases.

Methods

A systematic search was conducted in the Scopus database on November 5, 2024, encompassing studies from 1983 to 2024. A total of 4711 articles were retrieved using controlled descriptors and Boolean operators targeting CEUS in hepatic contexts. Bibliometric mapping was performed using VOSviewer (v1.6.19) and Biblioshiny. Metrics included annual scientific output, citation analysis, author/institution productivity, keyword co-occurrence, and country collaborations.

Results

CEUS publications increased exponentially after 2000, peaking in 2021 with 440 articles, and declining to 326 in 2024. China led in total publications (10 427), followed by Japan (5182), while Italy had the highest citation count (12 770). Hepatocellular carcinoma was the most recurrent keyword (872 mentions), followed by “liver” (464), “MRI” (178), and “AI” (29), indicating a shift toward multimodal and computational imaging. Clustering analyses identified four major thematic areas: oncologic applications, ablation techniques, microbubble innovation, and AI integration.

Conclusion

This is the first large-scale bibliometric analysis focused exclusively on CEUS in liver diseases. The findings highlight CEUS as a mature yet dynamic research field, with emerging emphasis on precision imaging and AI. Despite a recent decline in publication volume, scientific impact remains substantial.

Study Implications

These findings reinforce the clinical relevance of CEUS in liver imaging and support future research integrating standardized reporting and advanced analytic approaches to further enhance diagnostic accuracy and clinical translation.

查看原文本刊更多论文

肝脏疾病对比增强超声全球趋势和研究前沿的文献计量和可视化分析。

目的：本研究旨在进行全面的文献计量分析，以绘制对比增强超声（CEUS）应用于肝脏疾病的全球研究趋势、主题集中度和知识差距。方法：系统检索于2024年11月5日Scopus数据库中1983 - 2024年的相关文献。使用控制描述符和布尔运算符检索了4711篇针对肝脏背景下CEUS的文章。使用VOSviewer （v1.6.19）和Biblioshiny进行文献计量制图。指标包括年度科学产出、引文分析、作者/机构生产力、关键词共现和国家合作。结果：2000年后CEUS的发表量呈指数增长，2021年达到峰值440篇，2024年下降到326篇。中国的总论文发表数最多（10427篇），其次是日本（5182篇），而意大利的引用数最多（12770篇）。肝细胞癌是最常见的关键词（872次提及），其次是“肝脏”（464次）、“MRI”（178次）和“人工智能”（29次），表明向多模式和计算成像的转变。聚类分析确定了四个主要主题领域：肿瘤学应用、消融技术、微泡创新和人工智能集成。结论：这是第一个专门针对肝脏疾病超声造影的大规模文献计量学分析。研究结果表明，超声造影是一个成熟而充满活力的研究领域，其重点是精密成像和人工智能。尽管最近出版物数量有所下降，但科学影响仍然很大。研究意义：这些发现加强了超声造影在肝脏成像中的临床意义，并支持未来整合标准化报告和先进分析方法的研究，以进一步提高诊断准确性和临床翻译。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Ultrasound 医学-核医学

CiteScore

1.90

自引率

0.00%

发文量

248

审稿时长

6 months

期刊介绍： The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography. The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents. JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.