Impact of the mindfulness-based blood pressure reduction (MB-BP) program on cardiovascular health: A randomized clinical trial

IF 5.4 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

American journal of preventive cardiology Pub Date : 2026-06-01 Epub Date: 2026-03-28 DOI:10.1016/j.ajpc.2026.101584

Fan Wu , LaPrincess C. Brewer , Vinicius V. Neves , Matthew M. Scarpaci , Frances B. Saadeh , Jeffrey A. Proulx , Eric B. Loucks

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Abstract

Background

Mindfulness-based interventions may improve cardiovascular health (CVH) by supporting behavioral change across multiple risk factors. This study evaluated the impact of Mindfulness-Based Blood Pressure Reduction (MB-BP), a mindfulness program targeting hypertension-related behaviors, on CVH using the American Heart Association’s Life’s Essential 8 framework.

Methods

This secondary analysis of parallel-group, phase 2 randomized clinical trial evaluated the effects of MB-BP on CVH in 201 participants with elevated office BP (≥120/80 mmHg). The MB-BP group (n=101) received an 8-week program focused on mindfulness training and education targeting diet, physical activity, medication adherence, alcohol use, and stress, whereas the control group (n=100) received enhanced usual care. CVH was assessed using available Life’s Essential 8 components: systolic blood pressure, body mass index (BMI), diet (DASH adherence), physical activity, smoking, and sleep duration. Generalized estimating equations evaluated intervention effects through six months.

Results

At six months follow-up, MB-BP participants significantly improved composite CVH scores compared to controls (standardized mean difference: 0.144; 95% CI: 0.023, 0.266). MB-BP influenced most CVH components in healthier directions at trend levels, with the strongest responses for physical activity (47.9 MET min/week; 95% CI: -16.5, 112.3), sleep (0.34 hours/night; 95% CI: -0.10, 0.78), systolic blood pressure (-4.95 mmHg; 95% CI: -10.34, 0.44) and DASH diet score (0.27, 95% CI: -0.15, 0.69).

Conclusions

MB-BP led to modest but clinically relevant improvements in CVH, driven by multiple Life’s Essential 8 components. These findings suggest that MB-BP may be an effective behavioral intervention to support CVH and reduce risk for cardiovascular disease.

ClinicalTrials.gov Preregistration Identifiers: NCT03256890, NCT03859076

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正念降压（MB-BP）计划对心血管健康的影响：一项随机临床试验

背景：基于正念的干预可以通过支持跨多个危险因素的行为改变来改善心血管健康。本研究使用美国心脏协会的生命基本8框架评估了正念降压（MB-BP）对CVH的影响。正念降压是一种针对高血压相关行为的正念项目。方法：这项平行组2期随机临床试验评估了MB-BP对201例血压升高（≥120/80 mmHg）患者CVH的影响。MB-BP组（n=101）接受了为期8周的计划，重点是正念训练和针对饮食、体育活动、药物依从性、酒精使用和压力的教育，而对照组（n=100）接受了强化的常规护理。CVH的评估采用可用的生命基本8项指标：收缩压、体重指数（BMI）、饮食（DASH依从性）、身体活动、吸烟和睡眠时间。广义估计方程评估了六个月的干预效果。结果在6个月的随访中，MB-BP参与者与对照组相比显著提高了CVH综合评分（标准化平均差：0.144;95% CI: 0.023, 0.266）。MB-BP在趋势水平上影响了大多数CVH成分，其中对身体活动（47.9 MET min/week; 95% CI: -16.5, 112.3）、睡眠（0.34小时/晚；95% CI: -0.10, 0.78）、收缩压（-4.95 mmHg; 95% CI: -10.34, 0.44）和DASH饮食评分（0.27,95% CI: -0.15, 0.69）的反应最强。结论：在多种Life 's Essential 8组件的驱动下，smb - bp可导致CVH的适度但临床相关的改善。这些发现表明MB-BP可能是一种有效的行为干预，支持CVH和降低心血管疾病的风险

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