Lorena Suárez Portugués, José A Carnicero, Alonso Sepúlveda Martínez, Fabio A Quiñónez Bareiro, Ana Alfaro Acha, Ignacio Ara, Leocadio Rodriguez Mañas, Francisco J García García
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引用次数: 0
Abstract
Background: Frailty is a geriatric syndrome defined as increased vulnerability to stressors due to dysfunction in multiple physiological systems, measured by different tools.
Objectives: To assess whether participants characterized as frail by multiple scales simultaneously have differentiated risks.
Setting and participants: Community-dwelling adults from the first wave of The Toledo Study for Healthy Aging (TSHA), including a total of 1.563 participants with a mean age of 74.51 years. Frailty was assessed using three tools: the Frailty Index (FI), the Fried Phenotype, and the Frailty Trait Scale (FTS-5). Eight groups were defined based on the presence or absence of frailty according to these scales. Associations between frailty categories and outcomes were evaluated using multivariate Cox proportional hazards models for mortality and logistic regression models for incident and worsening disability.
Results: The FTS-5 scale identified the highest number of frail participants, suggesting it may be the most sensitive tool for detecting early physiological changes related to aging. Risk of adverse events varied depending on the specific combination of frailty criteria met. Individuals classified as frail by both FTS-5 and FI exhibited the highest mortality risk, exceeding that of participants frail on all three scales. Regarding worsening health or disability, the highest risk was among those frails on all three scales, followed closely by the FTS-5-FI group.
Conclusion: Our findings highlight variability in frailty assessment, showing that different instruments capture complementary aspects of frailty and that their combined use may improve risk stratification.
期刊介绍：
The Journal of Frailty & Aging is a peer-reviewed international journal aimed at presenting articles that are related to research in the area of aging and age-related (sub)clinical conditions. In particular, the journal publishes high-quality papers describing and discussing social, biological, and clinical features underlying the onset and development of frailty in older persons. The Journal of Frailty & Aging is composed by five different sections: - Biology of frailty and aging In this section, the journal presents reports from preclinical studies and experiences focused at identifying, describing, and understanding the subclinical pathophysiological mechanisms at the basis of frailty and aging. - Physical frailty and age-related body composition modifications Studies exploring the physical and functional components of frailty are contained in this section. Moreover, since body composition plays a major role in determining physical frailty and, at the same time, represents the most evident feature of the aging process, special attention is given to studies focused on sarcopenia and obesity at older age. - Neurosciences of frailty and aging The section presents results from studies exploring the cognitive and neurological aspects of frailty and age-related conditions. In particular, papers on neurodegenerative conditions of advanced age are welcomed. - Frailty and aging in clinical practice and public health This journal’s section is devoted at presenting studies on clinical issues of frailty and age-related conditions. This multidisciplinary section particularly welcomes reports from clinicians coming from different backgrounds and specialties dealing with the heterogeneous clinical manifestations of advanced age. Moreover, this part of the journal also contains reports on frailty- and age-related social and public health issues. - Clinical trials and therapeutics This final section contains all the manuscripts presenting data on (pharmacological and non-pharmacological) interventions aimed at preventing, delaying, or treating frailty and age-related conditions.The Journal of Frailty & Aging is a quarterly publication of original papers, review articles, case reports, controversies, letters to the Editor, and book reviews. Manuscripts will be evaluated by the editorial staff and, if suitable, by expert reviewers assigned by the editors. The journal particularly welcomes papers by researchers from different backgrounds and specialities who may want to share their views and experiences on the common themes of frailty and aging.The abstracting and indexing of the Journal of Frailty & Aging is covered by MEDLINE (approval by the National Library of Medicine in February 2016).
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