Neuropsychological endophenotypes of substance use vulnerability in freelance professional artists: implications for personalized medicine

IF 2.1

Personalized Medicine in Psychiatry Pub Date : 2026-06-01 Epub Date: 2026-05-27 DOI:10.1016/j.pmip.2026.100189

Lucila Ortiz Vazquez , Yaveth Ruvalcaba Delgadillo , Victor Hugo Carrera Escobedo , Fernando Jáuregui Huerta

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引用次数: 0

Abstract

Objective

To delineate the neuropsychological endophenotypes driving alcohol and substance use vulnerability among freelance professional artists, examining the interplay of personality dysregulation, intellectual capacity, and gender-moderated pathways.

Method

We conducted a deep clinical phenotyping of 42 freelance professional artists in Mexico (50% women; mean age = 28.5). We integrated standardized measures of personality pathology (MMPI-2), intelligence (WAIS-IV), and alcohol risk (AUDIT) using Mexican population norms. Data were analyzed via hierarchical regression and two-step cluster analysis.

Results

Alcohol risk was predicted by traits of low behavioral control (social responsibility; β = −0.28) and high self-perceived addiction potential (β = 0.59), whereas WAIS-IV intelligence indices exerted no universal protective or risk effects. Critically, gender moderated risk expression: hypomania and trauma-related externalizing traits strongly predicted AUDIT scores in men (r = 0.47) but not in women (r = 0.14), who exhibited more internalizing profiles. Cluster analysis identified three etiologically distinct endophenotypes: a high-risk disinhibited profile (62.5% male) characterized by unconventional thought, executive deficits (working memory), and severe alcohol misuse; a high-resource impulsive profile with superior intelligence but elevated hypomania; and a regulated profile (66.7% female) exhibiting high social responsibility and minimal risk.

Conclusion

Substance use vulnerability in the freelance creative workforce is driven by personality dysregulation and executive functioning deficits rather than intellectual capacity or creative talent per se. Identifying these gender-specific, trauma-informed endophenotypes provides a critical background for personalized medicine, enabling tailored therapeutic interventions that move beyond generic addiction protocols.

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自由职业艺术家物质使用脆弱性的神经心理内表型：对个性化医疗的影响

目的描述自由职业艺术家中驱动酒精和物质使用脆弱性的神经心理内表型，研究人格失调、智力能力和性别调节通路之间的相互作用。方法对42名墨西哥自由职业艺术家（50%为女性，平均年龄28.5岁）进行深度临床表型分析。我们使用墨西哥人口标准整合了人格病理（MMPI-2）、智力（WAIS-IV）和酒精风险（AUDIT）的标准化测量。采用层次回归和两步聚类分析对数据进行分析。结果低行为控制（社会责任，β = - 0.28）和高自我感知成瘾潜能（β = 0.59）是预测酒精风险的主要因素，而WAIS-IV智力指标没有普遍的保护或风险作用。重要的是，性别调节了风险表达：轻躁狂和创伤相关的外化特征强烈地预测了男性的审计分数（r = 0.47），但对女性没有（r = 0.14），她们表现出更多的内化特征。聚类分析确定了三种病因学上不同的内表型：高风险去抑制型（62.5%男性），以非常规思维、执行能力缺陷（工作记忆）和严重酒精滥用为特征；高资源冲动性，高智商但轻度躁狂；受监管的形象（66.7%为女性）表现出高度的社会责任和最小的风险。结论自由职业创造性劳动力的物质使用脆弱性是由人格失调和执行功能缺陷驱动的，而不是由智力能力或创造性才能本身驱动的。识别这些性别特异性的、创伤知情的内表型为个性化医疗提供了重要背景，使定制的治疗干预能够超越通用的成瘾方案。

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来源期刊

Personalized Medicine in Psychiatry

CiteScore

1.40

自引率

0.00%

发文量