Running Therapy Reorganizes Dynamic Brain Networks Linked to Symptom Improvement in Affective Disorders

IF 4.9 2区医学 Q1 NEUROSCIENCES

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Pub Date : 2026-10-01 Epub Date: 2026-06-05 DOI:10.1016/j.bpsc.2026.05.011

Julian Gaviria Lopez, Guido Van Wingen, Chris Vriend, Laura K.M. Han, Jennifer Labus, Gitte M. Knudsen, Brenda W.J.H. Penninx

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引用次数: 0

Abstract

Background

Exercise therapy reduces depressive and anxiety symptoms, but its neural mechanisms remain unclear. We examined whether running therapy reorganizes dynamic brain functional connectivity in affective disorders (AFFs).

Methods

Resting-state functional magnetic resonance imaging was analyzed at baseline in 66 healthy control participants and 50 individuals with AFFs. Coactivation pattern (CAP) analysis identified recurring whole-brain states and their temporal dynamics. After baseline comparisons, patients received 16 weeks of running therapy or antidepressant treatment. Then, we examined treatment-related CAP changes and their associations with symptom improvement.

Results

At baseline, individuals with AFFs showed fewer occurrences and shorter dwell time of the visual-somatosensory-subcortical CAP (VS-SC_CAP) than control participants (both ps ≤ .04, η_p² ≈ 0.04–0.05). Running therapy induced a treatment-specific reorganization of brain dynamics, with decreased default mode CAP (DM_CAP) occurrences (F = 8.18, p = .01, η_p² = 0.13) and dwell time (F = 11.51, p < .001, η_p² = 0.19) and increased VS-SC_CAP occurrences (F = 8.10, p = .01, η_p² = 0.13) and entries (F = 5.39, p = .03, η_p² = 0.08). Greater reductions in DM_CAP entries and transitions from DM_CAP to VS-SC_CAP were associated with greater improvement in anxiety- and fear-related symptoms (ρ = −0.54 to −0.45, all q ≤ .03).

Conclusions

Running therapy was associated with treatment-specific reorganization of large-scale brain dynamics in AFFs. Symptom improvement was linked to changes in DM CAP dynamics and transitions between DM and VS states.

查看原文本刊更多论文

跑步疗法重组与情感障碍症状改善相关的动态大脑网络。

背景：运动疗法可减轻抑郁和焦虑症状，但其神经机制尚不清楚。我们研究了跑步疗法是否重组了情感性障碍患者的动态脑功能连接。方法：对66名健康对照者和50名情感性障碍患者的静息状态fMRI进行基线分析。共激活模式（CAP）分析确定了反复出现的全脑状态及其时间动态。在基线比较后，患者接受16周的跑步治疗或抗抑郁治疗。然后我们检查了治疗相关的CAP变化及其与症状改善的关系。结果：在基线时，情感性障碍个体的视觉-躯体感觉-皮质下CAP （VS-SCCAP）出现次数少于对照组，停留时间短于对照组（p≤0.04,η2p≈0.04 ~ 0.05）。跑步治疗诱导了治疗特异性脑动力学重组，降低了默认模式CAP （DMCAP）发生率（F = 8.18, p= 0.01, η2p= 0.13）和停留时间（F = 11.51, p < 0.001, η2p= 0.19），增加了VS-SCCAP发生率（F = 8.10, p= 0.01, η2p= 0.13）和进入率（F = 5.39, p= 0.03, η2p= 0.08）。DMCAP进入量的减少和从DMCAP到VS-SCCAP的转变与焦虑和恐惧相关症状的改善相关（rho = -0.54至-0.45，所有pFDR≤0.03）。结论：跑步治疗与情感性障碍患者大规模脑动力学的治疗特异性重组有关。症状改善与默认模式CAP动态的变化以及默认模式和视觉-体感状态之间的转换有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biological Psychiatry-Cognitive Neuroscience and Neuroimaging Neuroscience-Biological Psychiatry

CiteScore

10.40

自引率

1.70%

发文量

247

审稿时长

30 days

期刊介绍： Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.