Reference ranges for myocardial native T1, T2, and extracellular volume at 5.0T cardiac magnetic resonance imaging in healthy adults.

IF 5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Magnetic Resonance Pub Date : 2026-06-04 DOI:10.1016/j.jocmr.2026.102753

Shiyu Wang, Xianling Qian, Yali Wu, Xiyin Miao, Ziyun Guan, Dong Wang, Rui Wang, Yinyin Chen, Ling Chen, Zhuolin Liu, Shaofeng Duan, Lin Tian, Hang Jin, Mengsu Zeng

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引用次数: 0

Abstract

Background: A 5.0T Cardiovascular magnetic resonance (CMR) offers potential advantages over 3.0T systems, including improved signal-to-noise ratio and spatial resolution. Although myocardial T1 and T2 mapping techniques are increasingly applied in clinical practice, reference ranges for these parameters at 5.0T have not yet been established. The aim of this study is to determine normal reference values for myocardial native T1, T2 relaxation times, and extracellular volume fraction (ECV) in healthy adults using 5.0T CMR.

Methods: This prospective study enrolled 181 healthy Chinese adults aged 20-80 years who underwent 5.0T CMR. T1 and T2 mapping of the left ventricle were performed using a motion-corrected modified Look-Locker inversion recovery sequence and a T2-prepared single-shot sequence, respectively. Global and segmental myocardial T1, T2, and ECV values were quantified. Associations with sex, age, body mass index (BMI), and myocardial thickness were analyzed.

Results: The mean global myocardial T1, T2, and ECV values were 1496 ± 37 ms, 35 ± 3 ms and 27 ± 2 %, respectively. Females showed significantly higher T1 and T2 values than males (T1: 1509 ± 35 ms vs 1483 ± 35 ms, p<.001; T2: 36 ± 2 ms vs 34 ± 2 ms, p<.001). No significant age-related differences were observed. T1, T2, and ECV values were inversely associated with BMI (T1: r=-0.16, p=.034; T2: r=-0.35, p<.001; ECV: r=-0.31, p=.015). T1 values positively correlated with myocardial thickness (r=0.19, p<.001), whereas T2 and ECV values negatively correlated with thickness (r=-0.21 and -0.19, respectively; both p<.001). Segmental analysis showed lower T1 but higher T2 and ECV values at the apex compared with the mid and basal myocardium (all p<.001).

Conclusion: This study establishes normative myocardial T1, T2, and ECV values at 5.0T CMR in healthy adults. Myocardial tissue characteristics were influenced by sex, BMI, and myocardial thickness, with regional variations observed across myocardial segments.

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健康成人5.0T心脏MRI心肌原生T1、T2和细胞外体积的参考范围

背景：5.0T心血管磁共振（CMR）与3.0T系统相比具有潜在的优势，包括改进的信噪比和空间分辨率。虽然心肌T1和T2测图技术在临床中的应用越来越多，但这些参数在5.0T时的参考范围尚未建立。本研究的目的是利用5.0T CMR确定健康成人心肌原生T1、T2舒张时间和细胞外体积（ECV）的正常参考值。方法：本前瞻性研究纳入181名20 ~ 80岁的健康中国成年人，接受5.0T CMR。分别使用运动校正后的改良Look-Locker反转恢复序列和T2准备的单镜头序列进行左心室T1和T2映射。量化心肌整体和节段T1、T2和ECV值。分析其与性别、年龄、身体质量指数（BMI）和心肌厚度的关系。结果：心肌T1、T2、ECV均值分别为1496±37ms、35±3ms、27±2%。女性T1和T2值明显高于男性（T1: 1509±35ms vs 1483±35ms）。结论：本研究建立了健康成人5.0T CMR时心肌T1、T2和ECV值的标准。心肌组织特征受性别、BMI和心肌厚度的影响，在心肌节段之间存在区域性差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Magnetic Resonance 医学-核医学

CiteScore

10.90

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Magnetic Resonance (JCMR) publishes high-quality articles on all aspects of basic, translational and clinical research on the design, development, manufacture, and evaluation of cardiovascular magnetic resonance (CMR) methods applied to the cardiovascular system. Topical areas include, but are not limited to: New applications of magnetic resonance to improve the diagnostic strategies, risk stratification, characterization and management of diseases affecting the cardiovascular system. New methods to enhance or accelerate image acquisition and data analysis. Results of multicenter, or larger single-center studies that provide insight into the utility of CMR. Basic biological perceptions derived by CMR methods.