Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis.

Abstract

A well-defined jawline is an important aspect of facial aesthetics, contributing to overall appearance. This feature is particularly sought after by individuals, especially older adults, who are interested in enhancing their facial contours. This systematic review and meta-analysis evaluates safety and effectiveness following use of VYC-25L, a hyaluronic acid-based injectable gel, for restoration of jawline definition. VYC-25L is a soft tissue filler designed to add volume, lift, and contour to the jawline area, providing a non-surgical solution for improving facial aesthetics. This meta-analysis included two randomized controlled trials and three cohort studies of international databases-PubMed, EMBASE, Web of Science, and Cochrane Library-from January 2015 to May 2025, using keywords aligned with the study objective. The VYC-25L group had significantly higher responder rates on the Allergan Loss of Jawline Definition Scale (ALJDS) compared to the control group (71%; p < 0.001; 95% confidence interval [CI] [48%, 94%]). The most common event was swelling (effect size [ES]: 81%; 95% CI [69%, 92%]), lumps/bumps (ES: 83%; 95% CI [66%, 99%]), pain after injection (ES: 79%; 95% CI [62%, 96%]), and tenderness to touch (ES: 76%; 95% CI [61%, 92%]). In summary, VYC-25L appears to be an effective treatment for jawline definition, with a predictable adverse event profile.