Phage therapy via receptor-constrained evolutionary traps.

IF 18.7 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2026-09-01 Epub Date: 2026-06-04 DOI:10.1016/j.tim.2026.05.011

Yong E Zhang, Youming Zhang

引用次数: 0

Abstract

Phage therapy often fails when bacteria evolve resistance. We argue that phage selection should begin with receptors whose modification imposes predictable costs, turning resistance into reduced virulence, antibiotic resensitization, or other exploitable trade-offs. Receptor-constrained evolutionary traps offer a framework for designing phages that steer-not merely suppress-bacterial evolution effectively.

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通过受体约束进化陷阱的噬菌体治疗。

当细菌产生耐药性时，噬菌体疗法往往会失败。我们认为噬菌体的选择应该从受体开始，受体的修饰会带来可预测的成本，将抗性转化为降低毒力、抗生素再敏化或其他可利用的权衡。受受体约束的进化陷阱为设计噬菌体提供了一个框架，可以有效地引导——而不仅仅是抑制——细菌的进化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.