Renal Replacement Therapy in Cardiovascular-Kidney-Metabolic Syndrome: Challenges for Dialytic Therapies and Kidney Transplantation.

IF 3.2 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiorenal Medicine Pub Date : 2026-01-01 Epub Date: 2026-06-04 DOI:10.1159/000552830

Mahtab Mashayekhi, Jasjot Bhullar, Zohreh Gholizadeh Ghozloujeh, Sayna Norouzi, Khalil Pathan, Amir Abdipour

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引用次数: 0

Abstract

Background: Cardiovascular-kidney-metabolic (CKM) syndrome integrates the strong interrelationship among cardiovascular disease, chronic kidney disease (CKD), and metabolic risk factors such as obesity and diabetes.

Summary: Renal replacement therapy (RRT) is considered an essential component of management in advanced CKD. Kidney failure has unique therapeutic and prognostic challenges, particularly with the coexistence of heart failure, ischemic heart disease, and metabolic syndrome. In this review, we aim to evaluate challenges and therapeutic considerations in dialytic therapies and kidney transplantation in patients with CKM syndrome.

Key messages: Patients with CKM syndrome undergoing RRT represent a complex and vulnerable population requiring multidisciplinary and individualized management approaches. Optimization of cardiovascular and metabolic risk factors is essential to improve outcomes in dialysis and kidney transplantation settings.

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CKM的肾脏替代治疗：透析治疗和肾移植的挑战。

心血管-肾代谢（CKM）综合征整合了心血管疾病（CVD）、慢性肾脏疾病（CKD）和代谢危险因素（如肥胖和糖尿病）之间的密切相互关系。肾脏替代疗法（RRT）被认为是晚期CKD治疗的重要组成部分。肾衰竭具有独特的治疗和预后挑战，特别是与心力衰竭，缺血性心脏病和代谢综合征共存。在这篇综述中，我们旨在评估CKM综合征患者透析治疗和肾移植的挑战和治疗考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiorenal Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-UROLOGY & NEPHROLOGY

CiteScore

5.40

自引率

2.60%

发文量

审稿时长

>12 weeks

期刊介绍： The journal ''Cardiorenal Medicine'' explores the mechanisms by which obesity and other metabolic abnormalities promote the pathogenesis and progression of heart and kidney disease (cardiorenal metabolic syndrome). It provides an interdisciplinary platform for the advancement of research and clinical practice, focussing on translational issues.