Leveraging STRAW +10 criteria to evaluate menopause stage effects on sleep quality.

IF 3.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2026-10-01 Epub Date: 2026-06-05 DOI:10.1080/13697137.2026.2675563

Shelby C Wood, Jacob L van Doorn, Susan Y Bookheimer, Thomas E Nichols, Beau M Ances, Robert C Welsh, Pauline M Maki

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引用次数: 0

Abstract

Objective: The Stages of Reproductive Aging Workshop +10 (STRAW +10) criteria are the gold standard criteria for categorizing menopause stage, with stage typically categorized using three menopause stages. Although STRAW +10 criteria include additional substages, few studies have examined menopause symptoms by these substages. To better characterize menopause stage effects on sleep, this study examined sleep quality across three stages and six substages of menopause. To differentiate menopause effects from aging effects, the study further examined associations between age and sleep quality.

Method: Participants included 239 women aged 40-60 years from the Human Connectome Project in Aging (HCP-A) and the Aging Adult Brain Connectome (AABC). Sleep was measured using the Pittsburgh Sleep Quality Index and menopause was staged according to STRAW +10 criteria using three stages and six substages. All analyses were conducted using mixed-effects models.

Results: Independent of age, sleep quality declined linearly across six substages of menopause, but not three stages of menopause. Age was unrelated to sleep quality after adjustment for menopause stage.

Conclusion: Midlife represents a window of vulnerability to incrementally worse sleep associated with reproductive, but not chronological, aging. Findings highlight the benefit of using STRAW +10 substaging in menopause research.

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利用STRAW +10标准评价绝经期对睡眠质量的影响。

目的：生殖衰老阶段研讨会+10 （STRAW +10）标准是划分更年期阶段的金标准标准，通常使用三个更年期阶段进行分类。虽然STRAW +10标准包括其他亚阶段，但很少有研究通过这些亚阶段检查更年期症状。为了更好地描述更年期对睡眠的影响，这项研究考察了更年期的三个阶段和六个亚阶段的睡眠质量。为了区分更年期效应和衰老效应，该研究进一步研究了年龄和睡眠质量之间的关系。方法：参与者包括239名年龄在40-60岁之间的女性，她们来自人类衰老连接组项目（HCP-A）和衰老成人脑连接组（AABC）。采用匹兹堡睡眠质量指数（Pittsburgh Sleep Quality Index）对睡眠进行测量，绝经期按照STRAW +10标准分为3个阶段和6个亚阶段。所有分析均采用混合效应模型。结果：与年龄无关，睡眠质量在绝经的六个亚阶段呈线性下降，但在绝经的三个阶段没有。绝经期调整后，年龄与睡眠质量无关。结论：中年代表了一个易受越来越差的睡眠影响的窗口期，这与生殖衰老有关，而不是时间上的衰老。研究结果强调了在更年期研究中使用STRAW +10亚分期的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.