Exploring New Frontiers in Bone Metabolism: Role and Potential of lncRNA DANCR.

IF 4.4 2区生物学 Q1 CELL BIOLOGY

Wiley Interdisciplinary Reviews: RNA Pub Date : 2026-05-01 DOI:10.1002/wrna.70047

Mianmian Yang, Ruiqi Huang, Ruiming Wen, Haining Gao, Bo Chang, Xuejie Yi

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引用次数: 0

Abstract

As an emerging epigenetic regulator, differentiation-antagonizing long-chain noncoding RNA (lncRNA) plays multiple roles in bone metabolism regulation and bone-related diseases. We found that lncRNA DANCR regulates bone metabolism by inhibiting bone formation and promoting resorption. Additionally, it plays a crucial role in chondrogenesis and maintaining bone homeostasis. Under pathological conditions, lncRNA DANCR is involved in osteoarthritis and osteoporosis progression and malignant development of osteosarcoma. Here, we summarize the multiple roles of lncRNA DANCR in bone metabolism, discuss the interactions of lncRNA DANCR with microRNAs and multiple signaling pathways, and construct a network framework for bone metabolism regulation. We conclude that lncRNA DANCR is a key regulator of exercise, pharmacological interventions, and polymeric compounds in combating bone diseases. These findings extend our understanding of the function of lncRNA DANCR and provide important clues for the development of further therapeutic strategies. This article is categorized under: RNA in Disease and Development > RNA in Disease.

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探索骨代谢的新领域：lncRNA DANCR的作用和潜力。

分化拮抗长链非编码RNA （lncRNA）作为一种新兴的表观遗传调控因子，在骨代谢调控和骨相关疾病中发挥着多种作用。我们发现lncRNA DANCR通过抑制骨形成和促进骨吸收来调节骨代谢。此外，它在软骨形成和维持骨稳态中起着至关重要的作用。病理条件下，lncRNA DANCR参与骨关节炎和骨质疏松的进展以及骨肉瘤的恶性发展。本文总结lncRNA DANCR在骨代谢中的多重作用，讨论lncRNA DANCR与microrna及多种信号通路的相互作用，构建骨代谢调控的网络框架。我们得出结论，lncRNA DANCR是运动、药物干预和抗击骨病的聚合物化合物的关键调节因子。这些发现扩展了我们对lncRNA DANCR功能的理解，并为进一步开发治疗策略提供了重要线索。本文分类如下：RNA在疾病和发展> RNA在疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiley Interdisciplinary Reviews: RNA CELL BIOLOGY-

CiteScore

14.80

自引率

4.10%

发文量

审稿时长

6-12 weeks

期刊介绍： WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.