COVID-19-Associated Rhabdomyolysis in Hospitalized Patients: Retrospective Cohort Study.

IF 2.1 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Saudi Medical Journal Pub Date : 2026-06-01 Epub Date: 2026-05-13 DOI:10.15537/1658-3175.8794

Paula Esquerdo-Serrano, Silvia Otero-Rodriguez, Hector Pinargote-Celorio, Sergio Reus, Esperanza Merino, José-Manuel Ramos-Rincón

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引用次数: 0

Abstract

Objectives: To determine the frequency of rhabdomyolysis in patients hospitalized with COVID-19 and to characterize their clinical features and outcomes.

Methods: All adults admitted to the hospital were included in this single-center retrospective cohort study with COVID-19 at a tertiary care institution in Alicante, Spain, between March 2020 and March 2024. A creatine kinase (CK) threshold of 1000 U/L or higher was used to define rhabdomyolysis. Demographic, clinical, laboratory, treatment, and outcome data were collected. Patients with and without rhabdomyolysis were compared, and factors associated with in-hospital mortality (IHM) were analyzed.

Results: Among 7,590 hospitalized COVID-19 patients, 20 developed rhabdomyolyses (cumulative incidence 0.26%; 95% CI 0.170.41). Most affected patients were male (85%), and male sex demonstrated an independent relationship with rhabdomyolysis (adjusted OR 4.35; 95% CI 1.2714.94). Acute kidney injury was observed in 60% of patients, and 15% required hemodialysis. IHM was markedly higher among patients with rhabdomyolysis than in those without (35% vs. 11.5%) (adjusted OR 4.24; 95% CI 1.4812.10).

Conclusion: Rhabdomyolysis was an uncommon but severe complication of COVID-19, predominantly affecting men and frequently inked to acute kidney failure and high IHM.

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住院患者covid -19相关横纹肌溶解：回顾性队列研究

目的：了解2019冠状病毒病住院患者横纹肌溶解的发生频率，并分析其临床特征和预后。方法：2020年3月至2024年3月，在西班牙阿利坎特的一家三级医疗机构，所有入院的成年人都被纳入了这项COVID-19单中心回顾性队列研究。肌酸激酶（CK）阈值为1000 U/L或更高用于定义横纹肌溶解。收集了人口统计学、临床、实验室、治疗和结局数据。对有和没有横纹肌溶解的患者进行比较，并分析与住院死亡率（IHM）相关的因素。结果：7590例住院COVID-19患者中，20例出现横纹肌溶解（累计发病率0.26%,95% CI 0.170.41）。大多数受影响的患者为男性（85%），男性与横纹肌溶解有独立的关系（调整后OR为4.35；95% CI为1.2714.94）。60%的患者出现急性肾损伤，15%的患者需要血液透析。横纹肌溶解患者的IHM明显高于无横纹肌溶解患者（35% vs. 11.5%）（校正OR 4.24; 95% CI 1.4812.10）。结论：横纹肌溶解是COVID-19罕见但严重的并发症，主要影响男性，常与急性肾衰竭和高IHM相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Saudi Medical Journal 医学-医学：内科

CiteScore

2.30

自引率

6.20%

发文量

203

审稿时长

12 months

期刊介绍： The Saudi Medical Journal is a monthly peer-reviewed medical journal. It is an open access journal, with content released under a Creative Commons attribution-noncommercial license. The journal publishes original research articles, review articles, Systematic Reviews, Case Reports, Brief Communication, Brief Report, Clinical Note, Clinical Image, Editorials, Book Reviews, Correspondence, and Student Corner.