Associations between estimated glucose disposal rate and peripheral artery disease: evidence from the UK Biobank and NHANES.

IF 3.9 2区医学 Q2 NUTRITION & DIETETICS

Nutrition & Metabolism Pub Date : 2026-06-03 DOI:10.1186/s12986-026-01149-6

Jilang Zeng, Xinjie Zeng, Weihong Lin, Xinjun Lin, Feng Hu, Lin Fan, Cheng Yu, Lianglong Chen

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引用次数: 0

Abstract

Background: Insulin resistance (IR) is considered a key pathogenic mechanism of peripheral artery disease (PAD). The estimated glucose disposal rate (eGDR) serves as a practical surrogate marker of IR. The study aimed to investigate the association between eGDR and incident PAD risk in the general population.

Methods: A total of 456,743 participants free of PAD at baseline were included from the prospective UK Biobank cohort. In addition, we examined the cross-sectional association between eGDR and prevalent PAD among 7,208 participants from the National Health and Nutrition Examination Survey (NHANES) as a supplementary analysis.

Results: Multivariable Cox regression analysis showed that participants in the highest eGDR quartile (Q4) experienced the greatest reduction in the risk of developing PAD compared with the reference group [Q4 vs. Q1; fully adjusted hazard ratio (HR) = 0.67, 95% confidence interval (CI): 0.63-0.72, P < 0.001]. Restricted cubic spline (RCS) curve and threshold effect analysis also suggested a significant nonlinear inverse relationship between eGDR and PAD risk, with an inflection point at 7.829 (P for overall < 0.001; P for nonlinearity < 0.001). Two-piecewise Cox regression further indicated that below the threshold, an increase in eGDR was associated with a greater reduction in PAD risk (HR = 0.85, 95% CI: 0.84-0.87, P < 0.001). A similar inverse association between eGDR and prevalent PAD was observed in the NHANES analysis.

Conclusions: eGDR was inversely associated with PAD. Further studies are needed to explore the clinical utility of this association.

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估计葡萄糖处理率与外周动脉疾病之间的关系：来自英国生物银行和NHANES的证据。

背景：胰岛素抵抗（Insulin resistance， IR）被认为是外周动脉疾病（PAD）的重要致病机制。估计葡萄糖处置率（eGDR）作为IR的实用替代标志物。该研究旨在调查普通人群中eGDR与PAD事件风险之间的关系。方法：基线时无PAD的456,743名参与者从英国生物银行前瞻性队列中纳入。此外，作为补充分析，我们在全国健康与营养检查调查（NHANES）的7208名参与者中检查了eGDR与普遍PAD之间的横断面关联。结果：多变量Cox回归分析显示，与对照组相比，eGDR最高四分位数（Q4）的参与者患PAD的风险降低幅度最大[Q4 vs. Q1；完全校正风险比(HR) = 0.67, 95%可信区间（CI）： 0.63-0.72， P结论：eGDR与PAD呈负相关。需要进一步的研究来探索这种关联的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition & Metabolism 医学-营养学

CiteScore

8.40

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition & Metabolism publishes studies with a clear focus on nutrition and metabolism with applications ranging from nutrition needs, exercise physiology, clinical and population studies, as well as the underlying mechanisms in these aspects. The areas of interest for Nutrition & Metabolism encompass studies in molecular nutrition in the context of obesity, diabetes, lipedemias, metabolic syndrome and exercise physiology. Manuscripts related to molecular, cellular and human metabolism, nutrient sensing and nutrient–gene interactions are also in interest, as are submissions that have employed new and innovative strategies like metabolomics/lipidomics or other omic-based biomarkers to predict nutritional status and metabolic diseases. Key areas we wish to encourage submissions from include: -how diet and specific nutrients interact with genes, proteins or metabolites to influence metabolic phenotypes and disease outcomes; -the role of epigenetic factors and the microbiome in the pathogenesis of metabolic diseases and their influence on metabolic responses to diet and food components; -how diet and other environmental factors affect epigenetics and microbiota; the extent to which genetic and nongenetic factors modify personal metabolic responses to diet and food compositions and the mechanisms involved; -how specific biologic networks and nutrient sensing mechanisms attribute to metabolic variability.