Identification of Neonatal Prevalence Trends in Gastroschisis: 2016–2024

IF 2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2026-06-04 DOI:10.1002/bdr2.70066

Stephanie A. Eyerly-Webb, Amanda J. Nickel, Eric Dion, Clifton O. Brock, Saul Snowise, James Fisher

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引用次数: 0

Abstract

Background

Gastroschisis prevalence in the United States has varied over the last several decades, with recent reports indicating a downward trend through 2022.

Objective/Methods

To determine if this trend continued beyond the COVID-19 Public Health Emergency, we examined data from the Children's Hospital Association's Pediatric Health Information System (PHIS) for critically ill neonates admitted from 2016 to 2024.

Results

The national prevalence for critically ill neonates with gastroschisis significantly decreased (p ≤ 0.0001) between 2016 and 2024, with consistent declines across all regions in the United States. In contrast, trends for congenital diaphragmatic hernia and intestinal atresias remained stable or increased during the same period. We observed a −31.1% change in the prevalence of gastroschisis in critically ill neonates using PHIS, which was similar to the changes reported using population-level data sets from the Centers for Disease Control (−34.2%, −32.3%).

Conclusions

These results indicate an ongoing decline in gastroschisis prevalence in the critically ill neonatal population, similar to changes seen at the population level, highlighting the need to explore potential causes.

查看原文本刊更多论文

新生儿胃裂病流行趋势的识别：2016-2024。

背景：在过去的几十年里，胃裂的患病率在美国有所不同，最近的报告显示，到2022年，胃裂的患病率将呈下降趋势。目的/方法：为了确定这一趋势是否在COVID-19突发公共卫生事件之后继续存在，我们检查了儿童医院协会儿童卫生信息系统（PHIS）中2016年至2024年入院的危重新生儿的数据。结果：2016年至2024年间，全国危重新生儿胃裂患病率显著下降（p≤0.0001），美国所有地区均呈持续下降趋势。相比之下，先天性膈疝和肠闭锁的趋势在同一时期保持稳定或增加。我们观察到使用公共卫生信息系统（PHIS）的危重新生儿胃裂患病率的变化为-31.1%，这与使用疾病控制中心的人口水平数据集报告的变化相似（-34.2%,-32.3%）。结论：这些结果表明，危重新生儿群体胃裂患病率持续下降，与人群水平的变化相似，突出了探索潜在原因的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.