Association of Serum Levels of Ghrelin and NLRP3 with Diabetic Retinopathy.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2026-09-01 Epub Date: 2026-06-03 DOI:10.1080/02713683.2026.2682882

Xin Lu, Min Wang, Mei Yan, Hao Liu, Xiabo Li, Xuejing Zheng, Menghan Xu, Rong Li, Lihua Hou

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引用次数: 0

Abstract

Purpose: To investigate the serum levels of ghrelin and Nod-like receptor protein 3 (NLRP3) in patients with diabetic retinopathy (DR) and evaluate their correlation with DR progression.

Methods: Thirty-seven patients with DR admitted to the First People's Hospital of Xianyang between April 2024 and April 2025 were enrolled and classified into non-proliferative DR (NPDR) and proliferative DR (PDR) subgroups based on fundus lesion severity. Fifty-three patients with simple cataracts served as controls. Serum levels of ghrelin and NLRP3 were measured using enzyme-linked immunosorbent assay, and their relationship with systemic indicators was analyzed.

Results: Serum ghrelin and NLRP3 levels differed significantly between the PDR, NPDR, and control groups (p < 0.001). Pairwise comparisons revealed statistically significant differences in serum ghrelin levels between the PDR and control groups, as well as between the NPDR and control groups (both p < 0.017). Serum NLRP3 levels differed significantly between the PDR and control, the PDR and NPDR, and the NPDR and control groups (all p < 0.017). Serum ghrelin levels were positively correlated with high-density lipoprotein levels (r = 0.325, p < 0.05) and the use of statin lipid-lowering drugs (r_s = -0.397, p < 0.05).

Conclusions: Decreased serum ghrelin and elevated serum NLRP3 levels in patients with DR suggest that ghrelin and NLRP3 are involved in DR pathogenesis.

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血清Ghrelin和NLRP3水平与糖尿病视网膜病变的关系。

目的：探讨糖尿病视网膜病变（DR）患者血清ghrelin和nod样受体蛋白3 （NLRP3）水平及其与DR进展的相关性。方法：选取2024年4月~ 2025年4月咸阳市第一人民医院住院的37例DR患者，根据眼底病变严重程度分为非增殖性DR （NPDR）亚组和增殖性DR （PDR）亚组。53例单纯性白内障患者作为对照。采用酶联免疫吸附法检测血清ghrelin和NLRP3水平，并分析其与全身指标的关系。结果：血清ghrelin和NLRP3水平在PDR组、NPDR组和对照组之间差异有统计学意义（p p p r = 0.325, p rs = -0.397, p）。结论：DR患者血清ghrelin降低，NLRP3升高，提示ghrelin和NLRP3参与DR的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.