Histomorphometric Evaluation of the Tissue Response to Xenogeneic Extracellular Peritoneal Matrix and Synthetic UltraPro Mesh under Conditions of Pseudomonas aeruginosa Infection.
N T Abatov, R M Badyrov, N K Urazbayev, E K Kamyshanskiy, A V Lavrinenko, L L Akhmaltdinova, D K Esniyazov
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引用次数: 0
Abstract
We performed a comparative histomorphometric assessment of the tissue responses to two types of implants, xenogeneic extracellular peritoneal matrix (ECM) and synthetic UltraPro mesh, in laboratory rats with modeled Pseudomonas aeruginosa infection. Histological evaluation was carried out on days 10 and 20 after implantation of the tested materials under the anterior abdominal wall. ECM induced a pronounced inflammatory response accompanied by tissue necrosis at early post-implantation terms and followed by progressive tissue remodeling. In contrast, the UltraPro mesh induced a milder acute inflammatory reaction with a tendency toward chronic inflammation and fibrous capsule formation. This findings support the importance of evaluating the infectious burden during implant selection in clinical practice.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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