The Effect of Various Modes of Intermittent Normobaric Hypoxia on the Neurological and Hormonal Status of Rats.

IF 0.7 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2026-03-01 Epub Date: 2026-06-02 DOI:10.1007/s10517-026-06674-1

K A Baranova, M V Osipova, E A Rybnikova

引用次数: 0

Abstract

Hypoxic conditioning (HC) is a novel approach that employs intermittent hypoxia for health and wellness purposes, fundamentally differing from the well-known method of hypoxic training (HT). We compared the effects of various modes of HC and HT on the neurological and antioxidant status and the function of the hypothalamic-pituitary-adrenocortical axis and thyroid systems in rats. It was found that HC had a more beneficial effect on the nervous system, which was accompanied by a transient decrease in antioxidant activity in the hippocampus and an increase in blood glucocorticoid levels on the first day. HT inhibited the thyroid function, while conditioning regimens produced a less pronounced effect.

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不同模式间歇常压缺氧对大鼠神经和激素状态的影响。

低氧调节（HC）是一种利用间歇性缺氧来达到健康目的的新方法，与众所周知的低氧训练（HT）方法有根本区别。我们比较了不同模式的HC和HT对大鼠神经系统和抗氧化状态以及下丘脑-垂体-肾上腺皮质轴和甲状腺系统功能的影响。研究发现，HC对神经系统有更有益的作用，这伴随着第一天海马体内抗氧化活性的短暂下降和血液中糖皮质激素水平的增加。激素抑制甲状腺功能，而调理方案产生不太明显的效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.