M I Sungatullina, R I Zaripova, A M Sadykov, A L Zefirov, N I Ziyatdinova, T L Zefirov
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引用次数: 0
Abstract
We studied the effect of α2-adrenoreceptor stimulation on functional parameters of Langendorff-isolated heart from pubertal rats subjected to restriction of motor activity during the early postnatal ontogeny. Clonidine hydrochloride, an agonist of α2-adrenoreceptors, was used at concentrations of 10-9-10-6 M. After restriction of motor activity, stimulation of α2-adrenoreceptors with clonidine at the studied concentrations had a positive inotropic effect. α2-Adrenoreceptor stimulation led to a dose-dependent decrease in coronary flow, and this effect was more pronounced after hypokinesia. The role of α2-adrenoreceptors in the cardiovascular system under conditions of motor restriction requires further study considering age-related features.
期刊介绍：
Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005.
World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells.
The Russian Volume Year is published in English from April.
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