Perinatal Exposure Profiles to Bisphenols and Their Associations With Thyroid Hormones Changes

IF 2 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2026-06-02 DOI:10.1002/bdr2.70077

Abderrezak Khelfi, Inas Aouissi, Iyad Fara, Chakib Fesraoui, Mohamed Azzouz

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引用次数: 0

Abstract

Introduction

Bisphenols are ubiquitous endocrine disruptors suspected of interfering with several physiological functions. Their effects during the perinatal period are of particular concern due to the high vulnerability of this stage of development.

Objective

This study aimed to evaluate fetal exposure to bisphenols and to investigate possible associations between thyroid hormone levels and bisphenol concentrations.

Materials and Methods

A total of 154 mother–child pairs were included and umbilical cord blood samples were collected. Thyroid hormones (TSH, FT4, and FT3) and bisphenols (BPA, BPF, and BPS) were quantified in these samples. Relevant information about participants was obtained through a structured questionnaire.

Results

The prevalence of bisphenol detection in umbilical cord blood samples was 92.8% for BPA, 65.5% for BPS, and 57.8% for BPF. Mean concentrations in umbilical cord blood were 2.456, 0.646, and 0.660 ng/mL. Significant positive associations were observed between FT4 and the three bisphenols with β values of 0.740, 0.897, and 1.045, respectively. A significant positive association was also found between FT3 levels and BPA concentrations (β = 0.119).

Conclusion

This study highlights the detectable exposure of Algerian women to bisphenols, as well as the association of these compounds with thyroid changes during the perinatal period, with potential consequences for fetal development.

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围产期双酚暴露概况及其与甲状腺激素变化的关系。

双酚类物质是普遍存在的内分泌干扰物，可能干扰多种生理功能。由于这一发育阶段的高度脆弱性，它们在围产期的影响尤其令人关切。目的：本研究旨在评估胎儿双酚暴露，并探讨甲状腺激素水平与双酚浓度之间的可能关系。材料与方法：共纳入154对母婴，采集脐带血样本。甲状腺激素（TSH， FT4和FT3）和双酚（BPA， BPF和BPS）在这些样本中被量化。通过结构化问卷获得参与者的相关信息。结果：脐带血双酚检出率BPA为92.8%，BPS为65.5%，BPF为57.8%。脐带血平均浓度分别为2.456、0.646和0.660 ng/mL。β值分别为0.740、0.897和1.045，FT4与三种双酚类物质呈显著正相关。FT3水平与BPA浓度之间也存在显著正相关（β = 0.119）。结论：本研究强调了阿尔及利亚妇女可检测到的双酚暴露，以及这些化合物与围产期甲状腺变化的关联，对胎儿发育有潜在的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.