Transcranial Pulse Stimulation Enhances Dexterity in Parkinson's Disease: A Randomized Sham-Controlled Trial

IF 7.7 1区医学 Q1 CLINICAL NEUROLOGY

Movement Disorders Pub Date : 2026-09-24 Epub Date: 2026-06-01 DOI:10.1002/mds.70365

Eva Matt PhD, Nina Plischek MSc, Michael Mitterwallner PhD, Sonja Radjenovic PhD, Alexandra Weber MSc, Alina Domitner MSc, Gregor Dörl MSc, Anna Zettl MSc, Sarah Osou MSc, Anna Leitgeb BSc, Agnes Santer MD, Viktoria Winkler MD, Julia Mandelburger MD, Heidemarie Zach MD, PhD, Roland Beisteiner MD, MA

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引用次数: 0

Abstract

Background

Ultrasound-based neuromodulation, capable of reaching deep brain areas with high precision, represents cutting-edge technology in non-invasive brain stimulation and is investigated as a novel treatment for neurological and psychiatric disorders, including Parkinson's disease (PD).

Objectives

To evaluate the effects of repeated transcranial pulse stimulation (TPS) applications on motor symptoms, brain structure, and functional activation in PD.

Methods

In this randomized, sham-controlled, double-blind, crossover clinical trial, 30 participants with mild PD underwent six sessions of both verum and sham TPS targeting the sensorimotor network. Comprehensive clinical and magnetic resonance imaging (MRI) assessments were administered at baseline, 1 day, and 1 month post-stimulation for both conditions.

Results

Manual dexterity, measured via the coin rotation task, showed significantly larger improvement following verum compared with sham TPS (post-stimulation vs. baseline: P_corr = 0.048, ηp² = 0.14; 1-month post-stimulation vs. baseline: P_corr = 0.048, ηp² = 0.17). Gross motor symptoms, evaluated by the Movement Disorder Society-Unified Parkinson's Disease Rating Scale-Part III (MDS-UPDRS-III), improved similarly after both verum and sham TPS. Functional MRI during a coin rotation task revealed increased activation in the sensorimotor network following verum stimulation compared with sham (P < 0.001). Diffusion tensor imaging data indicated enhanced structural integrity in the primary somatosensory white matter following verum TPS compared with sham (P < 0.05 family-wise error [FWE]-corrected). A total of 21 adverse events were reported, all mild and transient.

Conclusions

These findings indicate that TPS produces behavioral, neurophysiological, and structural effects within the targeted sensorimotor network, and may represent a safe and effective adjunct to standard therapies in PD. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

查看原文本刊更多论文

经颅脉冲刺激提高帕金森病患者的灵活性：一项随机假对照试验。

背景：基于超声的神经调节，能够高精度到达脑深部区域，是无创脑刺激的前沿技术，被研究作为神经和精神疾病的新治疗方法，包括帕金森病（PD）。目的：评价反复经颅脉冲刺激（TPS）对PD患者运动症状、脑结构和功能激活的影响。方法：在这项随机、假对照、双盲、交叉临床试验中，30名轻度PD患者接受了6次针对感觉运动网络的verum和sham TPS。对两种情况分别在基线、刺激后1天和1个月进行全面的临床和磁共振成像（MRI）评估。结果：手灵巧性，通过硬币旋转任务测量，与假TPS相比，verum后显示出更大的改善（刺激后与基线：Pcorr = 0.048, ηp2 = 0.14；刺激后1个月与基线：Pcorr = 0.048, ηp2 = 0.17）。运动障碍学会统一帕金森病评定量表第三部分（MDS-UPDRS-III）评估的大运动症状在verum和假TPS后均有相似的改善。在旋转硬币任务期间的功能MRI显示，与假手术相比，扁桃体刺激后感觉运动网络的激活增加(P)。结论：这些发现表明，TPS在目标感觉运动网络中产生行为、神经生理和结构效应，可能是PD标准治疗的一种安全有效的辅助疗法。©2026作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.