tDCS Targeting the DLPFC for Reducing Cigarette Craving and Risky Decision Making.

IF 1.1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2025-09-01 DOI:10.32598/bcn.2025.2297.4

Saba Niknamfar, Kamaledin Alaedini, Azarakhsh Mokri, Eisa Nazar, Raheleh Rafaiee, Seyedeh Masoumeh Seyedhosseini Tamijani, Seyed Hamzeh Hosseini, Hamed Ghazvini

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引用次数: 0

Abstract

Introduction: Cigarette smoking is a prevalent addictive behavior. Despite its well-known health risks, many individuals are unable to quit. One of the key factors contributing to the failure of smoking cessation efforts is the presence of craving and the tendency toward risk-taking behaviors. Noninvasive brain stimulation techniques have recently emerged as potential treatments for addiction. The present study is a pilot trial examining the impact of transcranial direct current stimulation (tDCS) targeting the dorsolateral prefrontal cortex (DLPFC) on risk-taking, electroencephalogram frequency power, and their relationship with cue-induced nicotine craving in smokers.

Methods: In this double-blind study, which is part of a larger randomized clinical trial, 63 cigarette smokers who met the international classification of disease-10 (ICD-10) criteria for tobacco addiction were enrolled. tDCS sham, left anodal/right cathodal, and right anodal/left cathodal tDCS will be applied to three participant groups. Participants were required to refrain from smoking for at least 2 hours before the study visit. The effects of tDCS on cue-triggered nicotine craving, certain risky decision-making tasks, and some resting-state electroencephalography (EEG) frequency power analyses will be evaluated both before and after tDCS (2 mA for 20 minutes) applied to the DLPFC on 5 consecutive days.

Conclusion: Although several studies have reported that tDCS may have beneficial effects on drug abuse by suppressing the degrees of cravings, impulsivity, and risk decision making, to date, no study has evaluated the impact of tDCS on the DLPFC and its relationship with EEG frequency power characteristics. The results of this study are anticipated to represent a significant step toward improving smoking cessation efforts. The findings from this randomized controlled trial will explore the therapeutic potential of tDCS in treating nicotine addiction among smokers.

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tDCS针对DLPFC降低香烟渴望和风险决策。

吸烟是一种普遍的成瘾行为。尽管吸烟对健康的危害众所周知，但很多人还是戒不掉。导致戒烟努力失败的关键因素之一是渴望和冒险行为的倾向。非侵入性脑刺激技术最近成为治疗成瘾的潜在疗法。本研究是一项针对背外侧前额叶皮层（DLPFC）的经颅直流电刺激（tDCS）对吸烟者冒险行为、脑电图频率功率的影响及其与线索诱导的尼古丁渴望的关系的初步试验。方法：这项双盲研究是一项更大的随机临床试验的一部分，纳入了63名符合国际疾病分类-10 （ICD-10）烟草成瘾标准的吸烟者。三组参与者分别采用假手术、左阳极/右阴极、右阳极/左阴极tDCS。参与者被要求在研究访问前至少2小时不吸烟。在连续5天的tDCS （2 mA， 20分钟）应用于DLPFC前后，评估tDCS对线索触发的尼古丁渴望、某些风险决策任务和一些静息状态脑电图（EEG）频率功率分析的影响。结论：尽管一些研究报道了tDCS可能通过抑制渴望、冲动和风险决策的程度对药物滥用有有益的影响，但迄今为止，还没有研究评估了tDCS对DLPFC的影响及其与脑电图频率功率特性的关系。预计这项研究的结果将是朝着改善戒烟努力迈出的重要一步。这项随机对照试验的发现将探索tDCS治疗吸烟者尼古丁成瘾的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.